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Gene Review

NRTN  -  neurturin

Homo sapiens

Synonyms: NTN, Neurturin
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Disease relevance of NRTN


High impact information on NRTN


Biological context of NRTN


Anatomical context of NRTN


Associations of NRTN with chemical compounds

  • Activation of glutamate receptors in the striatum differentially regulates the expression of neurotrophins, glial cell line-derived neurotrophic factor (GDNF), neurturin, and their receptors in the striatum and in its connections, cortex, and substantia nigra, showing a selective trophic response against excitotoxic insults [16].
  • In comparison to that in age-matched NRTN(+/+) mice, aqueous tear production, tear fluorescein clearance, and corneal sensation were significantly reduced in NRTN(-/-) mice, whereas corneal permeability to AFD was significantly increased [13].

Other interactions of NRTN


Analytical, diagnostic and therapeutic context of NRTN


  1. GDNF and neurturin are target-derived factors essential for cranial parasympathetic neuron development. Hashino, E., Shero, M., Junghans, D., Rohrer, H., Milbrandt, J., Johnson, E.M. Development (2001) [Pubmed]
  2. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Doray, B., Salomon, R., Amiel, J., Pelet, A., Touraine, R., Billaud, M., Attié, T., Bachy, B., Munnich, A., Lyonnet, S. Hum. Mol. Genet. (1998) [Pubmed]
  3. GDNF - a stranger in the TGF-beta superfamily? Saarma, M. Eur. J. Biochem. (2000) [Pubmed]
  4. Idiopathic slow transit constipation and megacolon are not associated with neurturin mutations. Chen, B., Knowles, C.H., Scott, M., Anand, P., Williams, N.S., Milbrandt, J., Tam, P.K. Neurogastroenterol. Motil. (2002) [Pubmed]
  5. Expression of glial cell line-derived neurotrophic factor and neurturin in mature kidney, nephrogenic rests, and nephroblastoma: possible role as differentiating factors. Camassei, F.D., Boldrini, R., Jenkner, A., Inserra, A., Donfrancesco, A., Rava, L., Dominici, C. Pediatr. Dev. Pathol. (2003) [Pubmed]
  6. GDNF family receptor complexes are emerging drug targets. Bespalov, M.M., Saarma, M. Trends Pharmacol. Sci. (2007) [Pubmed]
  7. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Kordower, J.H., Herzog, C.D., Dass, B., Bakay, R.A., Stansell, J., Gasmi, M., Bartus, R.T. Ann. Neurol. (2006) [Pubmed]
  8. RET receptor expression in thyroid follicular epithelial cell-derived tumors. Bunone, G., Uggeri, M., Mondellini, P., Pierotti, M.A., Bongarzone, I. Cancer Res. (2000) [Pubmed]
  9. Regulation of neuromuscular synapse development by glial cell line-derived neurotrophic factor and neurturin. Wang, C.Y., Yang, F., He, X.P., Je, H.S., Zhou, J.Z., Eckermann, K., Kawamura, D., Feng, L., Shen, L., Lu, B. J. Biol. Chem. (2002) [Pubmed]
  10. Tissue distribution of neurturin, persephin and artemin in the human brainstem at fetal, neonatal and adult age. Quartu, M., Serra, M.P., Boi, M., Sestu, N., Lai, M.L., Del Fiacco, M. Brain Res. (2007) [Pubmed]
  11. Transient disruption of spermatogenesis by deregulated expression of neurturin in testis. Meng, X., Pata, I., Pedrono, E., Popsueva, A., de Rooij, D.G., Jänne, M., Rauvala, H., Sariola, H. Mol. Cell. Endocrinol. (2001) [Pubmed]
  12. Evolution of the GDNF family ligands and receptors. Airaksinen, M.S., Holm, L., Hätinen, T. Brain Behav. Evol. (2006) [Pubmed]
  13. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Song, X.J., Li, D.Q., Farley, W., Luo, L.H., Heuckeroth, R.O., Milbrandt, J., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  14. Loss of neurturin in frog-Comparative genomics study of GDNF family ligand-receptor pairs. Hätinen, T., Holm, L., Airaksinen, M.S. Mol. Cell. Neurosci. (2007) [Pubmed]
  15. GDNF family ligand immunoreactivity in the gut of teleostean fish. Lucini, C., Maruccio, L., Tafuri, S., Bevaqua, M., Staiano, N., Castaldo, L. Anat. Embryol. (2005) [Pubmed]
  16. Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease. Alberch, J., Pérez-Navarro, E., Canals, J.M. Brain Res. Bull. (2002) [Pubmed]
  17. Glial cell-line derived neurotrophic factor and neurturin regulate the expressions of distinct miRNA precursors through the activation of GFRalpha2. Yoong, L.F., Wan, G., Too, H.P. J. Neurochem. (2006) [Pubmed]
  18. GDNF family ligands display distinct action profiles on cultured GABAergic and serotonergic neurons of rat ventral mesencephalon. Ducray, A., Krebs, S.H., Schaller, B., Seiler, R.W., Meyer, M., Widmer, H.R. Brain Res. (2006) [Pubmed]
  19. Japanese patients with sporadic Hirschsprung: mutation analysis of the receptor tyrosine kinase proto-oncogene, endothelin-B receptor, endothelin-3, glial cell line-derived neurotrophic factor and neurturin genes: a comparison with similar studies. Sakai, T., Nirasawa, Y., Itoh, Y., Wakizaka, A. Eur. J. Pediatr. (2000) [Pubmed]
  20. A rapid assay for glial cell line-derived neurotrophic factor and neurturin based on transfection of cells with tyrosine hydroxylase promoter-luciferase construct. Tanaka, M., Xiao, H., Hirata, Y., Kiuchi, K. Brain Res. Brain Res. Protoc. (2003) [Pubmed]
  21. Differences and developmental changes in the responsiveness of PNS neurons to GDNF and neurturin. Forgie, A., Doxakis, E., Buj-Bello, A., Wyatt, S., Davies, A.M. Mol. Cell. Neurosci. (1999) [Pubmed]
  22. Transplantation of bone marrow stromal cells containing the neurturin gene in rat model of Parkinson's disease. Ye, M., Wang, X.J., Zhang, Y.H., Lu, G.Q., Liang, L., Xu, J.Y., Chen, S.D. Brain Res. (2007) [Pubmed]
  23. Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat. Bella, A.J., Fandel, T.M., Tantiwongse, K., Brant, W.O., Klein, R.D., Garcia, C.A., Lue, T.F. Journal of brachial plexus and peripheral nerve injury (2007) [Pubmed]
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