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Gene Review

NTF3  -  neurotrophin 3

Homo sapiens

Synonyms: HDNF, NGF-2, NGF2, NT-3, NT3, ...
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Disease relevance of NTF3


Psychiatry related information on NTF3


High impact information on NTF3


Chemical compound and disease context of NTF3


Biological context of NTF3


Anatomical context of NTF3


Associations of NTF3 with chemical compounds


Physical interactions of NTF3

  • The glial-cell-line-derived neurotrophic factor (GDNF) family receptors alpha (GFRalpha) are cell surface bound glycoproteins that mediate interactions of the GDNF ligand family with the RET receptor [34].
  • At the cellular level, NT3 binding to TrkCT1-tamalin induces Arf6 translocation to the membrane, which in turn causes membrane ruffling and the formation of cellular protrusions [35].
  • These observations suggest that sAPP(alpha) acts as an injury-induced neurotrophic factor that interacts with NGF to enhance neuronal viability using the insulin signaling pathway [36].

Enzymatic interactions of NTF3

  • Fibroblast growth factor-1 stimulation leads to phosphorylation of the adaptor protein Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target (SNT-1) on C-terminal tyrosine residues, whereas it is constitutively bound through its N-terminal phosphotyrosine-binding domain (PTB) to FGF receptors (FGFRs) [37].

Regulatory relationships of NTF3


Other interactions of NTF3


Analytical, diagnostic and therapeutic context of NTF3


  1. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. Nassenstein, C., Braun, A., Erpenbeck, V.J., Lommatzsch, M., Schmidt, S., Krug, N., Luttmann, W., Renz, H., Virchow, J.C. J. Exp. Med. (2003) [Pubmed]
  2. Peripheral neuropathies and neurotrophic factors: animal models and clinical perspectives. McMahon, S.B., Priestley, J.V. Curr. Opin. Neurobiol. (1995) [Pubmed]
  3. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Connor, B., Dragunow, M. Brain Res. Brain Res. Rev. (1998) [Pubmed]
  4. Brain-derived neurotrophic factor and neurotrophin-3 support the survival and neuritogenesis response of developing cochleovestibular ganglion neurons. Avila, M.A., Varela-Nieto, I., Romero, G., Mato, J.M., Giraldez, F., Van De Water, T.R., Represa, J. Dev. Biol. (1993) [Pubmed]
  5. Neurotrophins and neurotrophin receptors in human lung cancer. Ricci, A., Greco, S., Mariotta, S., Felici, L., Bronzetti, E., Cavazzana, A., Cardillo, G., Amenta, F., Bisetti, A., Barbolini, G. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  6. Sequential interactions of fibroblast growth factor-2, brain-derived neurotrophic factor, neurotrophin-3, and their receptors define critical periods in the development of cochlear ganglion cells. Hossain, W.A., Brumwell, C.L., Morest, D.K. Exp. Neurol. (2002) [Pubmed]
  7. Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains. Durany, N., Michel, T., Kurt, J., Cruz-Sánchez, F.F., Cervás-Navarro, J., Riederer, P. Int. J. Dev. Neurosci. (2000) [Pubmed]
  8. Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Cheng, C.Y., Hong, C.J., Yu, Y.W., Chen, T.J., Wu, H.C., Tsai, S.J. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  9. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Gervasoni, N., Aubry, J.M., Bondolfi, G., Osiek, C., Schwald, M., Bertschy, G., Karege, F. Neuropsychobiology (2005) [Pubmed]
  10. Glial cell line-derived neurotrophic factor concentration dependently improves disability and motor activity in MPTP-treated common marmosets. Costa, S., Iravani, M.M., Pearce, R.K., Jenner, P. Eur. J. Pharmacol. (2001) [Pubmed]
  11. Huntington's disease: new paths to pathogenesis. Ross, C.A. Cell (2004) [Pubmed]
  12. Extracellular crosstalk: when GDNF meets N-CAM. Zhou, F.Q., Zhong, J., Snider, W.D. Cell (2003) [Pubmed]
  13. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Allsopp, T.E., Wyatt, S., Paterson, H.F., Davies, A.M. Cell (1993) [Pubmed]
  14. ADDENDUM: Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Gill, S.S., Patel, N.K., Hotton, G.R., O'sullivan, K., McCarter, R., Bunnage, M., Brooks, D.J., Svendsen, C.N., Heywood, P. Nat. Med. (2006) [Pubmed]
  15. Antidepressants Increase Glial Cell Line-Derived Neurotrophic Factor Production through Monoamine-Independent Activation of Protein Tyrosine Kinase and Extracellular Signal-Regulated Kinase in Glial Cells. Hisaoka, K., Takebayashi, M., Tsuchioka, M., Maeda, N., Nakata, Y., Yamawaki, S. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  16. Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. Serres, F., Carney, S.L. Brain Res. (2006) [Pubmed]
  17. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Gill, S.S., Patel, N.K., Hotton, G.R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D.J., Svendsen, C.N., Heywood, P. Nat. Med. (2003) [Pubmed]
  18. Neuroprotective and neurorestorative properties of GDNF. Gash, D.M., Zhang, Z., Gerhardt, G. Ann. Neurol. (1998) [Pubmed]
  19. Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells. Caumont, A.S., Octave, J.N., Hermans, E. J. Neurochem. (2006) [Pubmed]
  20. Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse. Ozçelik, T., Rosenthal, A., Francke, U. Genomics (1991) [Pubmed]
  21. Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. Hattori, M., Kunugi, H., Akahane, A., Tanaka, H., Ishida, S., Hirose, T., Morita, R., Yamakawa, K., Nanko, S. Am. J. Med. Genet. (2002) [Pubmed]
  22. Brain-derived neurotrophic factor and neurotrophin-3 induce cell proliferation in the cochleovestibular ganglion through a glycosyl-phosphatidylinositol signaling system. Represa, J., Avila, M.A., Romero, G., Mato, J.M., Giraldez, F., Varela-Nieto, I. Dev. Biol. (1993) [Pubmed]
  23. The pharmacological potential of neurotrophins: a perspective. Vantini, G. Psychoneuroendocrinology (1992) [Pubmed]
  24. Cloning and expression of a cDNA encoding a novel human neurotrophic factor. Kaisho, Y., Yoshimura, K., Nakahama, K. FEBS Lett. (1990) [Pubmed]
  25. Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture. Hory-Lee, F., Russell, M., Lindsay, R.M., Frank, E. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  26. Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord. Thompson, S.W., Bennett, D.L., Kerr, B.J., Bradbury, E.J., McMahon, S.B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  27. Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases. Mufson, E.J., Kroin, J.S., Sendera, T.J., Sobreviela, T. Prog. Neurobiol. (1999) [Pubmed]
  28. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. Garzon, D., Yu, G., Fahnestock, M. J. Neurochem. (2002) [Pubmed]
  29. Association study of schizophrenia with polymorphisms at six candidate genes. Virgos, C., Martorell, L., Valero, J., Figuera, L., Civeira, F., Joven, J., Labad, A., Vilella, E. Schizophr. Res. (2001) [Pubmed]
  30. Brain-derived neurotrophic factor-, neurotrophin-3-, and tyrosine kinase receptor-like immunoreactivity in lingual taste bud fields of mature hamster. Ganchrow, D., Ganchrow, J.R., Verdin-Alcazar, M., Whitehead, M.C. J. Comp. Neurol. (2003) [Pubmed]
  31. The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics. Noga, O., Hanf, G., Schäper, C., O'Connor, A., Kunkel, G. Clin. Exp. Allergy (2001) [Pubmed]
  32. Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease. Alberch, J., Pérez-Navarro, E., Canals, J.M. Brain Res. Bull. (2002) [Pubmed]
  33. Protection by GDNF and Other Trophic Factors Against the Dopamine-Depleting Effects of Neurotoxic Doses of Methamphetamine. Cass, W.A., Peters, L.E., Harned, M.E., Seroogy, K.B. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  34. Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. Vanhorne, J.B., Gimm, O., Myers, S.M., Kaushik, A., von Deimling, A., Eng, C., Mulligan, L.M. Hum. Genet. (2001) [Pubmed]
  35. A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin. Esteban, P.F., Yoon, H.Y., Becker, J., Dorsey, S.G., Caprari, P., Palko, M.E., Coppola, V., Saragovi, H.U., Randazzo, P.A., Tessarollo, L. J. Cell Biol. (2006) [Pubmed]
  36. Characterization of the neurotrophic interaction between nerve growth factor and secreted alpha-amyloid precursor protein. Luo, J.J., Wallace, M.S., Hawver, D.B., Kusiak, J.W., Wallace, W.C. J. Neurosci. Res. (2001) [Pubmed]
  37. Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells. Manuvakhova, M., Thottassery, J.V., Hays, S., Qu, Z., Rentz, S.S., Westbrook, L., Kern, F.G. Oncogene (2006) [Pubmed]
  38. Alpha-synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors. Satoh, J.I., Kuroda, Y. Parkinsonism Relat. Disord. (2001) [Pubmed]
  39. Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. Fukuda, T., Kiuchi, K., Takahashi, M. J. Biol. Chem. (2002) [Pubmed]
  40. Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's disease. Lapchak, P.A., Araujo, D.M., Hilt, D.C., Sheng, J., Jiao, S. Brain Res. (1997) [Pubmed]
  41. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. McAllister, A.K., Katz, L.C., Lo, D.C. Neuron (1997) [Pubmed]
  42. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Sawai, H., Okada, Y., Kazanjian, K., Kim, J., Hasan, S., Hines, O.J., Reber, H.A., Hoon, D.S., Eibl, G. Cancer Res. (2005) [Pubmed]
  43. Neurotrophin trafficking by anterograde transport. Altar, C.A., DiStefano, P.S. Trends Neurosci. (1998) [Pubmed]
  44. Neurotrophin-directed differentiation of human adult marrow stromal cells to dopaminergic-like neurons. Tatard, V.M., D'Ippolito, G., Diabira, S., Valeyev, A., Hackman, J., McCarthy, M., Bouckenooghe, T., Menei, P., Montero-Menei, C.N., Schiller, P.C. Bone (2007) [Pubmed]
  45. Neurotrophin-3 and FLT3 tyrosine kinase receptor in perinatal life. Malamitsi-Puchner, A., Economou, E., Boutsikou, T., Nikolaou, K.E., Vrachnis, N. Mediators of inflammation. (2005) [Pubmed]
  46. The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. Mischel, P.S., Smith, S.G., Vining, E.R., Valletta, J.S., Mobley, W.C., Reichardt, L.F. J. Biol. Chem. (2001) [Pubmed]
  47. Human trabecular meshwork cells secrete neurotrophins and express neurotrophin receptors (Trk). Wordinger, R.J., Lambert, W., Agarwal, R., Talati, M., Clark, A.F. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  48. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Noga, O., Englmann, C., Hanf, G., Grützkau, A., Seybold, J., Kunkel, G. Clin. Exp. Allergy (2003) [Pubmed]
  49. Brain-derived neurotrophic factor-, neurotrophin-3-, and tyrosine kinase receptor-like immunoreactivity in lingual taste bud fields of mature hamster after sensory denervation. Ganchrow, D., Ganchrow, J.R., Verdin-Alcazar, M., Whitehead, M.C. J. Comp. Neurol. (2003) [Pubmed]
  50. Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro. Festuccia, C., Muzi, P., Gravina, G.L., Millimaggi, D., Speca, S., Dolo, V., Ricevuto, E., Vicentini, C., Bologna, M. Int. J. Oncol. (2007) [Pubmed]
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