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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNORD79  -  small nucleolar RNA, C/D box 79

Homo sapiens

Synonyms: RNU103, U79, Z22
 
 
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Disease relevance of SNORD79

  • Here, a RT-nested PCR coupled with a colorimetric plate hybridization assay was established to detect HHV-6 types A and B U79/80 mRNAs [1].
 

High impact information on SNORD79

  • Structure predictions of consensus sequences for the two classes of alpha-zeins, Z19 and Z22, were in good agreement with the alpha-helical contents determined by circular dichroism [2].
  • Using an e.l.i.s.a. with a monoclonal anti-(Z-DNA) antibody Z22, we found that hydralazine provoked the Z-DNA conformation in poly(dG-m5dC).poly(dG-m5dC) at 250-500 microM concentration [3].
  • The supercoiled form of hydralazine-treated plasmid bound to Z22 in a gel-retardation assay [3].
  • To develop additional cellular models for Zellweger syndrome, we produced a series of new mutant CHO cell clones in the same complementation group as Z78/C (Z2, Z7, Z22, and Z105) [4].
 

Analytical, diagnostic and therapeutic context of SNORD79

  • The alpha zein, the maize storage prolamin, is a mixture of several homologous polypeptides that shows two bands in SDS-PAGE, called Z19 and Z22 [5].

References

  1. A reverse transcription-nested PCR assay for HHV-6 mRNA early transcript detection after transplantation. Pradeau, K., Bordessoule, D., Szelag, J.C., Rolle, F., Ferrat, P., Meur, Y.L., Turlure, P., Denis, F., Ranger-Rogez, S. J. Virol. Methods (2006) [Pubmed]
  2. Solution conformational analysis of the alpha-zein proteins of maize. Tatham, A.S., Field, J.M., Morris, V.J., I'Anson, K.J., Cardle, L., Dufton, M.J., Shewry, P.R. J. Biol. Chem. (1993) [Pubmed]
  3. Hydralazine induces Z-DNA conformation in a polynucleotide and elicits anti(Z-DNA) antibodies in treated patients. Thomas, T.J., Seibold, J.R., Adams, L.E., Hess, E.V. Biochem. J. (1993) [Pubmed]
  4. Restoration of PEX2 peroxisome assembly defects by overexpression of PMP70. Gärtner, J., Brosius, U., Obie, C., Watkins, P.A., Valle, D. Eur. J. Cell Biol. (1998) [Pubmed]
  5. Conformation of the Z19 prolamin by FTIR, NMR, and SAXS. Forato, L.A., Doriguetto, A.C., Fischer, H., Mascarenhas, Y.P., Craievich, A.F., Colnago, L.A. J. Agric. Food Chem. (2004) [Pubmed]
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