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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pclo  -  piccolo (presynaptic cytomatrix protein)

Mus musculus

Synonyms: Acz, Aczonin, Brain-derived HLMN protein, Multidomain presynaptic cytomatrix protein, Pico, ...
 
 
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High impact information on Pclo

  • Analysis of the amino acid sequences of chicken and mouse aczonin indicates an organization into multiple domains, including two pairs of Cys(4) zinc fingers, a polyproline tract, and a PDZ domain and two C2 domains near the COOH terminus [1].
  • We report the identification and initial characterization of aczonin, a neuron-specific 550-kD protein concentrated at the presynaptic active zone and associated with a detergent-resistant cytoskeletal subcellular fraction [1].
  • Munc13 bound to the zinc finger domain of Rim1 but not to the rabphilin-3 or aczonin zinc fingers [2].
  • Pico-rna-virus stands for viruses which are small (pico), and have an RNA genome [3].
 

Analytical, diagnostic and therapeutic context of Pclo

  • The structures of 1 and 2 were assigned based upon their amino acid analyses on a Waters Pico Tag HPLC system and a chiral GC capillary column (Chirasil Val III), fast atom bombardment mass spectrometry (FABMS), high resolution FABMS, and tandem FABMS data [4].
  • Structures of these compounds were assigned based on their amino acid analysis with a Waters Pico Tag HPLC system plus fast atom bombardment mass spectrometry (FABMS), including tandem FABMS, analysis on the two new microcystins, [D-Glu(OCH3)6]microcystin-LR (1) and [D-Asp3, D-Glu(OCH3)6]microcystin-LR (2) [5].

References

  1. Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. Wang, X., Kibschull, M., Laue, M.M., Lichte, B., Petrasch-Parwez, E., Kilimann, M.W. J. Cell Biol. (1999) [Pubmed]
  2. Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs. Wang, X., Hu, B., Zimmermann, B., Kilimann, M.W. J. Biol. Chem. (2001) [Pubmed]
  3. The discovery of the enteroviruses and the classification of poliovirus among them. Melnick, J.L. Biologicals (1993) [Pubmed]
  4. Isolation and structures of microcystins from a cyanobacterial water bloom (Finland). Namikoshi, M., Sivonen, K., Evans, W.R., Sun, F., Carmichael, W.W., Rinehart, K.L. Toxicon (1992) [Pubmed]
  5. Two methyl ester derivatives of microcystins, cyclic heptapeptide hepatotoxins, isolated from Anabaena flos-aquae strain CYA 83/1. Sivonen, K., Skulberg, O.M., Namikoshi, M., Evans, W.R., Carmichael, W.W., Rinehart, K.L. Toxicon (1992) [Pubmed]
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