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Gene Review

Rims1  -  regulating synaptic membrane exocytosis 1

Mus musculus

Synonyms: C030033M19Rik, Kiaa0340, RIM 1, RIM1, RIM1a, ...
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Disease relevance of Rims1

  • Vector control activities consisted of spraying the cabins with residual insecticide, removing nesting materials, and "rodent proofing." This outbreak, the largest yet identified in North America, extends the known range of a principal vector and establishes the North Rim as an endemic source of tick-borne relapsing fever [1].
  • The combined protective effect of a novel naturally glycosylated Cu/Zn-containing superoxide dismutase, produced by the fungus Humicula lutea (HL-SOD) strain 103, and the selective anti-influenza drug rimantadine hydrochloride (Rim) was evaluated in experimental virus infection in mice, induced with influenza virus A/Aichi/2/68 (H3N2) [2].

High impact information on Rims1

  • Transfection of PC12 cells with the amino-terminal domains of Rim greatly enhances regulated exocytosis in a Rab3-dependent manner [3].
  • Rab3 is found only on synaptic vesicles, whereas Rim is localized to presynaptic active zones in conventional synapses, and to presynaptic ribbons in ribbon synapses [3].
  • We propose that Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles [3].
  • Large parts of aczonin, including the zinc finger, PDZ, and C2 domains, are homologous to Rim or to Bassoon, two other proteins concentrated in presynaptic active zones [4].
  • Rabphilin, Rim, and Noc2 have generally been believed to be the Rab3 isoform (Rab3A/B/C/D)-specific effectors that regulate secretory vesicle exocytosis in neurons and in some endocrine cells [5].

Biological context of Rims1

  • Adjacent sequences up to amino acid 387, encompassing differentially spliced sequences, the zinc finger module, and the SGAWFF motif of Rim1, did not significantly contribute to the strength or the specificity of Rab3 binding, whereas a point mutation within the helix (R33G) abolished binding [6].
  • Rim1 is a protein of the presynaptic active zone, the area of the plasma membrane specialized for neurotransmitter exocytosis, and interacts with Rab3, a small GTPase implicated in neurotransmitter vesicle dynamics [6].
  • Recent evidences in the fungi Aspergillus nidulans, Saccharomyces cerevisiae, Yarrowia lipolytica, and Candida albicans suggested that components of endosomal sorting complexes required for transport (ESCRT) involved in endocytic trafficking were needed for signal transduction along the Rim pathway [7].

Chemical compound and disease context of Rims1


Associations of Rims1 with chemical compounds

  • Pull-down experiments from brain lysate in the presence of cholate as detergent detected binding to downstream Rim1 sequences, between amino acids 56 and 387, of syntaxin and of Rab3 [6].

Other interactions of Rims1


Analytical, diagnostic and therapeutic context of Rims1

  • Here, we have studied the molecular determinants of Rim1 that are responsible for Rab3 binding, employing surface plasmon resonance and recombinant, bacterially expressed Rab3 and Rim1 proteins [6].
  • Spatial and temporal localization of PKC using confocal microscopy to visualize the PKC reporter dye, Rim-1, demonstrated localization of PKC to the lateral aspects of the forming second polar body after fertilization, or after artificial activation with calcium ionophore or PMA [10].


  1. Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park. Boyer, K.M., Munford, R.S., Maupin, G.O., Pattison, C.P., Fox, M.D., Barnes, A.M., Jones, W.L., Maynard, J.E. Am. J. Epidemiol. (1977) [Pubmed]
  2. Combined protective effect of a fungal Cu/Zn-containing superoxide dismutase and rimantadine hydrochloride in experimental murine influenza a virus infection. Serkedjieva, J., Roeva, I., Angelova, M., Dolashka, P., Voelter, W.G. Acta Virol. (2003) [Pubmed]
  3. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Wang, Y., Okamoto, M., Schmitz, F., Hofmann, K., Südhof, T.C. Nature (1997) [Pubmed]
  4. Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. Wang, X., Kibschull, M., Laue, M.M., Lichte, B., Petrasch-Parwez, E., Kilimann, M.W. J. Cell Biol. (1999) [Pubmed]
  5. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda, M. J. Biol. Chem. (2003) [Pubmed]
  6. Rim1 and rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal alpha -helix motifs. Wang, X., Hu, B., Zimmermann, B., Kilimann, M.W. J. Biol. Chem. (2001) [Pubmed]
  7. Deletions of endocytic components VPS28 and VPS32 affect growth at alkaline pH and virulence through both RIM101-dependent and RIM101-independent pathways in Candida albicans. Cornet, M., Bidard, F., Schwarz, P., Da Costa, G., Blanchin-Roland, S., Dromer, F., Gaillardin, C. Infect. Immun. (2005) [Pubmed]
  8. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Kiyonaka, S., Wakamori, M., Miki, T., Uriu, Y., Nonaka, M., Bito, H., Beedle, A.M., Mori, E., Hara, Y., De Waard, M., Kanagawa, M., Itakura, M., Takahashi, M., Campbell, K.P., Mori, Y. Nat. Neurosci. (2007) [Pubmed]
  9. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Yao, I., Takagi, H., Ageta, H., Kahyo, T., Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, S., Inokuchi, K., Ohtsuka, T., Macgregor, G.R., Tanaka, K., Setou, M. Cell (2007) [Pubmed]
  10. Activation of protein kinase C after fertilization is required for remodeling the mouse egg into the zygote. Gallicano, G.I., McGaughey, R.W., Capco, D.G. Mol. Reprod. Dev. (1997) [Pubmed]
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