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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Map4k4  -  mitogen-activated protein kinase kinase...

Mus musculus

Synonyms: 9430080K19Rik, AU043147, AU045934, AW046177, HGK, ...
 
 
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Disease relevance of Map4k4

  • These data strongly indicate that both the HGK motif and lysine residue (Lys487) play essential roles in inhibition of cell adhesion and invasion in vitro and in prevention of metastasis of cancer cells in vivo [1].
 

High impact information on Map4k4

  • Interestingly, chimeric analysis demonstrated that NIK has a cell nonautonomous function in stimulating migration of presomitic mesodermal cells away from the PS and a second cell autonomous function in stimulating the differentiation of presomitic mesoderm into dermomyotome [2].
  • P-5m (484GHGKHKNK491, Gly484-Lys491), an octapeptide including the HGK motif derived from D5H, and HGK, a tripeptide, inhibited both cell adhesion and invasion in vitro [1].
  • We tried to identify the HGK motif binding protein on the surface of cancer cells [1].
  • In this study, we found that the amino acid sequence His-Gly-Lys (HGK) in D5H is the core motif for inhibition of adhesion and invasion of MDA-MB-231 cells in vitro [1].
  • RESULTS: We have identified the Nck-interacting kinase (NIK), a member of the STE20/germinal center kinase (GCK) family, as a partner for the beta1A integrin cytoplasmic domain [3].

References

  1. Effect of His-Gly-Lys motif derived from domain 5 of high molecular weight kininogen on suppression of cancer metastasis both in vitro and in vivo. Kawasaki, M., Maeda, T., Hanasawa, K., Ohkubo, I., Tani, T. J. Biol. Chem. (2003) [Pubmed]
  2. Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Xue, Y., Wang, X., Li, Z., Gotoh, N., Chapman, D., Skolnik, E.Y. Development (2001) [Pubmed]
  3. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. Poinat, P., De Arcangelis, A., Sookhareea, S., Zhu, X., Hedgecock, E.M., Labouesse, M., Georges-Labouesse, E. Curr. Biol. (2002) [Pubmed]
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