Gene Review:
MAP4K4 - mitogen-activated protein kinase kinase...
Homo sapiens
Synonyms:
FLH21957, HEL-S-31, HGK, HPK/GCK-like kinase HGK, KIAA0687, ...
- Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Liang, J.J., Wang, H., Rashid, A., Tan, T.H., Hwang, R.F., Hamilton, S.R., Abbruzzese, J.L., Evans, D.B., Wang, H. Clin. Cancer Res. (2008)
- A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase. Collins, C.S., Hong, J., Sapinoso, L., Zhou, Y., Liu, Z., Micklash, K., Schultz, P.G., Hampton, G.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. Bouzakri, K., Zierath, J.R. J. Biol. Chem. (2007)
- A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. Yao, Z., Zhou, G., Wang, X.S., Brown, A., Diener, K., Gan, H., Tan, T.H. J. Biol. Chem. (1999)
- Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin. Kim, J.Y., Jung, K.J., Choi, J.S., Chung, H.Y. Aging Cell (2006)
- The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. Wright, J.H., Wang, X., Manning, G., LaMere, B.J., Le, P., Zhu, S., Khatry, D., Flanagan, P.M., Buckley, S.D., Whyte, D.B., Howlett, A.R., Bischoff, J.R., Lipson, K.E., Jallal, B. Mol. Cell. Biol. (2003)
- Functional identification of kinases essential for T-cell activation through a genetic suppression screen. Mack, K.D., Von Goetz, M., Lin, M., Venegas, M., Barnhart, J., Lu, Y., Lamar, B., Stull, R., Silvin, C., Owings, P., Bih, F.Y., Abo, A. Immunol. Lett. (2005)
- PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax. Wang, T., Lee, K., Rehman, A., Daoud, S.S. Biochem. Biophys. Res. Commun. (2007)
- Effects of Cot expression on the nuclear translocation of NF-kappaB in RBL-2H3 cells. Chikamatsu, S., Furuno, T., Kinoshita, Y., Inoh, Y., Hirashima, N., Teshima, R., Nakanishi, M. Mol. Immunol. (2007)