High impact information on Bcap31

• Down-regulation of BAP31 with small interfering RNA partially reversed the apoptosis [1].
• The expression level of P450 2C2 was significantly increased in COS-1 cells with repressed levels of BAP31 [1].
• BAP31 is involved in the retention of cytochrome P450 2C2 in the endoplasmic reticulum [1].
• Down-regulation of BAP31 expression with small interfering RNA resulted in redistribution of green fluorescent protein-tagged P450 2C2 or P450 2C1-(1-29) from the ER into the nuclear membrane and compact perinuclear compartment structures as well as the cell surface in a small fraction of the cells [1].
• Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response [2].

Biological context of Bcap31

• Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice [3].
• These results suggest that a compositional change of AMPA receptor (increase of GluR1) and upregulation of the Bap31 gene may be implicated in fatigue in mice [3].

Analytical, diagnostic and therapeutic context of Bcap31

• We have used bimolecular fluorescence complementation and co-immunoprecipitation to show that a ubiquitous ER membrane protein (BAP31) interacts with P450 2C2 in transfected COS-1 cells [1].

References