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Gene Review

AQP4  -  aquaporin 4

Bos taurus

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Psychiatry related information on AQP4

  • Significant increased expression levels of AQP1 (as revealed with two different antibodies) and AQP4 were seen in CJD, but not in advanced AD and DLB cases when compared with controls [1].

High impact information on AQP4

  • Immunohistochemistry revealed that AQP1 and AQP4 were expressed in astrocytes in diseased cases [1].
  • AQP1 and AQP4 protein levels were also studied in the cerebral cortex of BSE-infected bovine-PrP transgenic mice (BoPrP-Tg110 mice) examined at 60, 150, 210 and 270 days post-inoculation (dpi) compared with healthy brain-inoculated control mice [1].
  • No AQP1 staining was seen in corneal epithelium, and no staining was observed in CBCEC layers exposed to AQP3, AQP4, and AQP5 antibodies [2].

Analytical, diagnostic and therapeutic context of AQP4

  • However, a significant increase in the expression levels of AQP1 and AQP4 was found in mice at 270 dpi, the time corresponding with the appearance of PrP(res) immunoreactivity in Western blots and typical spongiform lesions in the brain [1].


  1. Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Rodr??guez, A., P??rez-Gracia, E., Espinosa, J.C., Pumarola, M., Torres, J.M., Ferrer, I. Acta Neuropathol. (2006) [Pubmed]
  2. Immunocytochemical localization of aquaporin-1 in bovine corneal endothelial cells and keratocytes. Wen, Q., Diecke, F.P., Iserovich, P., Kuang, K., Sparrow, J., Fischbarg, J. Exp. Biol. Med. (Maywood) (2001) [Pubmed]
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