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Gene Review

AQP4  -  aquaporin 4

Gallus gallus

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Disease relevance of AQP4

  • On the other hand, the mRNA expression of AQP4 in the kidney significantly decreased after dehydration [1].
  • Although the role of AQP4 in brain edema has been extensively investigated, little information exists regarding its functional role at the blood-brain barrier (BBB) [2].

Psychiatry related information on AQP4


High impact information on AQP4

  • In the tectum, telencephalon and cerebellum of 20-day embryos and chicks, aquaporin-4 strongly labeled the ependymal cells and the subpial glial membranes, as well as the bodies and processes of astroglial cells [3].
  • Aquaporin-4 (AQP4) is the major water channel expressed in brain perivascular astrocyte processes [2].
  • Results from studies on the chick optic tectum, a well-established model of BBB development, and the effect of lipopolysaccharide on the BBB integrity and on perivascular AQP4 expression have been analyzed and discussed [2].
  • Using Northern blotting analysis, AQP4 mRNA in chickens was observed as a band of approximately 5.5 kb in several tissues in addition to the hypothalamus, proventriculus, kidney, and breast muscle [1].
  • This suggests that AQP4 may play a pivotal role in osmoregulation in the chicken brain [1].

Biological context of AQP4

  • The nucleotide sequence of a chicken aquaporin 4 (AQP4) cDNA that encodes a protein of 335 amino acids showed high homology to mammalian AQP4 [1].

Anatomical context of AQP4


  1. Effect of water deprivation on aquaporin 4 (AQP4) mRNA expression in chickens (Gallus domesticus). Saito, N., Ikegami, H., Shimada, K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  2. The role of aquaporin-4 in the blood-brain barrier development and integrity: studies in animal and cell culture models. Nicchia, G.P., Nico, B., Camassa, L.M., Mola, M.G., Loh, N., Dermietzel, R., Spray, D.C., Svelto, M., Frigeri, A. Neuroscience (2004) [Pubmed]
  3. Role of aquaporin-4 water channel in the development and integrity of the blood-brain barrier. Nico, B., Frigeri, A., Nicchia, G.P., Quondamatteo, F., Herken, R., Errede, M., Ribatti, D., Svelto, M., Roncali, L. J. Cell. Sci. (2001) [Pubmed]
  4. Heterogeneous occurrence of aquaporin-4 in the ependyma and in the circumventricular organs in rat and chicken. Goren, O., Adorján, I., Kálmán, M. Anat. Embryol. (2006) [Pubmed]
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