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Gene Review

Aqp4  -  aquaporin 4

Mus musculus

Synonyms: AQP-4, Aquaporin-4, MIWC, Mercurial-insensitive water channel, WCH4, ...
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Disease relevance of Aqp4


Psychiatry related information on Aqp4


High impact information on Aqp4


Chemical compound and disease context of Aqp4


Biological context of Aqp4


Anatomical context of Aqp4


Associations of Aqp4 with chemical compounds


Other interactions of Aqp4


Analytical, diagnostic and therapeutic context of Aqp4


  1. Aquaporin 4 expression in the mammalian inner ear and its role in hearing. Mhatre, A.N., Stern, R.E., Li, J., Lalwani, A.K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. Song, Y., Fukuda, N., Bai, C., Ma, T., Matthay, M.A., Verkman, A.S. J. Physiol. (Lond.) (2000) [Pubmed]
  3. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Verkman, A.S., Yang, B., Song, Y., Manley, G.T., Ma, T. Exp. Physiol. (2000) [Pubmed]
  4. Characterization of aquaporin-4 in muscle and muscular dystrophy. Crosbie, R.H., Dovico, S.A., Flanagan, J.D., Chamberlain, J.S., Ownby, C.L., Campbell, K.P. FASEB J. (2002) [Pubmed]
  5. Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling. Yang, B., Zador, Z., Verkman, A.S. J. Biol. Chem. (2008) [Pubmed]
  6. Increased expression of water channel aquaporin 1 and aquaporin 4 in Creutzfeldt-Jakob disease and in bovine spongiform encephalopathy-infected bovine-PrP transgenic mice. Rodr??guez, A., P??rez-Gracia, E., Espinosa, J.C., Pumarola, M., Torres, J.M., Ferrer, I. Acta Neuropathol. (2006) [Pubmed]
  7. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Li, Z., Gao, L., Liu, Q., Cao, C., Sun, X.L., Ding, J.H., Hu, G. Neurosci. Lett. (2006) [Pubmed]
  8. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Manley, G.T., Fujimura, M., Ma, T., Noshita, N., Filiz, F., Bollen, A.W., Chan, P., Verkman, A.S. Nat. Med. (2000) [Pubmed]
  9. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. Lennon, V.A., Kryzer, T.J., Pittock, S.J., Verkman, A.S., Hinson, S.R. J. Exp. Med. (2005) [Pubmed]
  10. Lung fluid transport in aquaporin-5 knockout mice. Ma, T., Fukuda, N., Song, Y., Matthay, M.A., Verkman, A.S. J. Clin. Invest. (2000) [Pubmed]
  11. Increased seizure threshold in mice lacking aquaporin-4 water channels. Binder, D.K., Oshio, K., Ma, T., Verkman, A.S., Manley, G.T. Neuroreport (2004) [Pubmed]
  12. Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia. Turtzo, L.C., Lee, M.D., Lu, M., Smith, B.L., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Agre, P. Genomics (1997) [Pubmed]
  13. Impaired hearing in mice lacking aquaporin-4 water channels. Li, J., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  14. Immunolocalization of aquaporin homologs in mouse lacrimal glands. Ishida, N., Hirai, S.I., Mita, S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  15. Ultrastructural localization of aquaporin 4 and alpha1-syntrophin in the vascular feet of brain astrocytes. Inoue, M., Wakayama, Y., Liu, J.W., Murahashi, M., Shibuya, S., Oniki, H. Tohoku J. Exp. Med. (2002) [Pubmed]
  16. Distribution of Aquaporin 4 in rodent spinal cord: relationship with astrocyte markers and chondroitin sulfate proteoglycans. Vitellaro-Zuccarello, L., Mazzetti, S., Bosisio, P., Monti, C., De Biasi, S. Glia (2005) [Pubmed]
  17. Altered expression of aquaporin 4 and H(+)/K(+)-ATPase in the stomachs of peptide YY (PYY) transgenic mice. Carmosino, M., Mazzone, A., Laforenza, U., Gastaldi, G., Svelto, M., Valenti, G. Biol. Cell (2005) [Pubmed]
  18. Aquaporin-5 dependent fluid secretion in airway submucosal glands. Song, Y., Verkman, A.S. J. Biol. Chem. (2001) [Pubmed]
  19. Aquaporin-4 expression in adult and developing mouse and rat kidney. Kim, Y.H., Earm, J.H., Ma, T., Verkman, A.S., Knepper, M.A., Madsen, K.M., Kim, J. J. Am. Soc. Nephrol. (2001) [Pubmed]
  20. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. Bai, C., Fukuda, N., Song, Y., Ma, T., Matthay, M.A., Verkman, A.S. J. Clin. Invest. (1999) [Pubmed]
  21. Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice. Nico, B., Frigeri, A., Nicchia, G.P., Corsi, P., Ribatti, D., Quondamatteo, F., Herken, R., Girolamo, F., Marzullo, A., Svelto, M., Roncali, L. Glia (2003) [Pubmed]
  22. Polarized trafficking of the aquaporin-3 water channel is mediated by an NH2-terminal sorting signal. Rai, T., Sasaki, S., Uchida, S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  23. Physiology and pathophysiology of renal aquaporins. Kwon, T.H., Hager, H., Nejsum, L.N., Andersen, M.L., Frøkiaer, J., Nielsen, S. Semin. Nephrol. (2001) [Pubmed]
  24. Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin-4. Frigeri, A., Nicchia, G.P., Balena, R., Nico, B., Svelto, M. FASEB J. (2004) [Pubmed]
  25. Role of aquaporin water channels in airway fluid transport, humidification, and surface liquid hydration. Song, Y., Jayaraman, S., Yang, B., Matthay, M.A., Verkman, A.S. J. Gen. Physiol. (2001) [Pubmed]
  26. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. van Hoek, A.N., Ma, T., Yang, B., Verkman, A.S., Brown, D. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  27. The role of aquaporin-4 in the blood-brain barrier development and integrity: studies in animal and cell culture models. Nicchia, G.P., Nico, B., Camassa, L.M., Mola, M.G., Loh, N., Dermietzel, R., Spray, D.C., Svelto, M., Frigeri, A. Neuroscience (2004) [Pubmed]
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