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MeSH Review

Epithelium, Corneal

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Disease relevance of Epithelium, Corneal


High impact information on Epithelium, Corneal

  • In situ hybridization analysis did not detect CHST6 transcripts in corneal epithelium in an MCD type II patient, suggesting that the mutations found in type II lead to loss of cornea-specific expression of CHST6 [6].
  • Meesmann's corneal dystrophy (MCD) is an autosomal dominant disorder causing fragility of the anterior corneal epithelium, where K3 and K12 are specifically expressed [7].
  • EGF has diverse biological activities: it is a potent mitogen for many tissue culture cells, inhibits gastric acid secretion from the intestinal mucosa and promotes healing of the corneal epithelium [8].
  • Northern blots of mRNA from chicken corneal epithelium, MDCK cells, and various human tissues indicated that pinin messages exhibit tissue-specific variation in size, ranging from 3.2 to 4.1 kb [9].
  • Heparan sulfate proteoglycans with gonococcal binding activity were purified from various cell types derived from target tissues of gonococcal infection, including ME-180 endocervical cells and primary cultures of human corneal epithelium [10].

Chemical compound and disease context of Epithelium, Corneal


Biological context of Epithelium, Corneal


Anatomical context of Epithelium, Corneal


Associations of Epithelium, Corneal with chemical compounds


Gene context of Epithelium, Corneal


Analytical, diagnostic and therapeutic context of Epithelium, Corneal


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  3. Familial subepithelial corneal amyloidosis--a lactoferrin-related amyloidosis. Klintworth, G.K., Valnickova, Z., Kielar, R.A., Baratz, K.H., Campbell, R.J., Enghild, J.J. Invest. Ophthalmol. Vis. Sci. (1997) [Pubmed]
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  7. Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy. Irvine, A.D., Corden, L.D., Swensson, O., Swensson, B., Moore, J.E., Frazer, D.G., Smith, F.J., Knowlton, R.G., Christophers, E., Rochels, R., Uitto, J., McLean, W.H. Nat. Genet. (1997) [Pubmed]
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  17. Role of lumican in the corneal epithelium during wound healing. Saika, S., Shiraishi, A., Liu, C.Y., Funderburgh, J.L., Kao, C.W., Converse, R.L., Kao, W.W. J. Biol. Chem. (2000) [Pubmed]
  18. Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. Pappa, A., Brown, D., Koutalos, Y., DeGregori, J., White, C., Vasiliou, V. J. Biol. Chem. (2005) [Pubmed]
  19. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. Makino, Y., Kanopka, A., Wilson, W.J., Tanaka, H., Poellinger, L. J. Biol. Chem. (2002) [Pubmed]
  20. Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. Stepp, M.A., Gibson, H.E., Gala, P.H., Iglesia, D.D., Pajoohesh-Ganji, A., Pal-Ghosh, S., Brown, M., Aquino, C., Schwartz, A.M., Goldberger, O., Hinkes, M.T., Bernfield, M. J. Cell. Sci. (2002) [Pubmed]
  21. Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy. Nishida, K., Honma, Y., Dota, A., Kawasaki, S., Adachi, W., Nakamura, T., Quantock, A.J., Hosotani, H., Yamamoto, S., Okada, M., Shimomura, Y., Kinoshita, S. Am. J. Hum. Genet. (1997) [Pubmed]
  22. Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Sivak, J.M., West-Mays, J.A., Yee, A., Williams, T., Fini, M.E. Mol. Cell. Biol. (2004) [Pubmed]
  23. Overexpression of matrix metalloproteinase-10 and matrix metalloproteinase-3 in human diabetic corneas: a possible mechanism of basement membrane and integrin alterations. Saghizadeh, M., Brown, D.J., Castellon, R., Chwa, M., Huang, G.H., Ljubimova, J.Y., Rosenberg, S., Spirin, K.S., Stolitenko, R.B., Adachi, W., Kinoshita, S., Murphy, G., Windsor, L.J., Kenney, M.C., Ljubimov, A.V. Am. J. Pathol. (2001) [Pubmed]
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  25. Platelet-activating factor induces collagenase expression in corneal epithelial cells. Bazan, H.E., Tao, Y., Bazan, N.G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  26. 12(R)-hydroxyicosatetraenoic acid: a cytochrome-P450-dependent arachidonate metabolite that inhibits Na+,K+-ATPase in the cornea. Schwartzman, M.L., Balazy, M., Masferrer, J., Abraham, N.G., McGiff, J.C., Murphy, R.C. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  27. 12(R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium. Murphy, R.C., Falck, J.R., Lumin, S., Yadagiri, P., Zirrolli, J.A., Balazy, M., Masferrer, J.L., Abraham, N.G., Schwartzman, M.L. J. Biol. Chem. (1988) [Pubmed]
  28. Role of the Lewis(x) glycan determinant in corneal epithelial cell adhesion and differentiation. Cao, Z., Zhao, Z., Mohan, R., Alroy, J., Stanley, P., Panjwani, N. J. Biol. Chem. (2001) [Pubmed]
  29. Requirement for Pax6 in corneal morphogenesis: a role in adhesion. Davis, J., Duncan, M.K., Robison, W.G., Piatigorsky, J. J. Cell. Sci. (2003) [Pubmed]
  30. Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cells. Budak, M.T., Alpdogan, O.S., Zhou, M., Lavker, R.M., Akinci, M.A., Wolosin, J.M. J. Cell. Sci. (2005) [Pubmed]
  31. Cdk5 regulates activation and localization of Src during corneal epithelial wound closure. Gao, C.Y., Stepp, M.A., Fariss, R., Zelenka, P. J. Cell. Sci. (2004) [Pubmed]
  32. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Song, X.J., Li, D.Q., Farley, W., Luo, L.H., Heuckeroth, R.O., Milbrandt, J., Pflugfelder, S.C. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  33. Increased expression of inflammatory cytokines and matrix metalloproteinases in pseudophakic corneal edema. Shoshani, Y., Pe'er, J., Doviner, V., Frucht-Pery, J., Solomon, A. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  34. Redistribution of the hemidesmosome components alpha 6 beta 4 integrin and bullous pemphigoid antigens during epithelial wound healing. Gipson, I.K., Spurr-Michaud, S., Tisdale, A., Elwell, J., Stepp, M.A. Exp. Cell Res. (1993) [Pubmed]
  35. Alpha-enolase is restricted to basal cells of stratified squamous epithelium. Zieske, J.D., Bukusoglu, G., Yankauckas, M.A., Wasson, M.E., Keutmann, H.T. Dev. Biol. (1992) [Pubmed]
  36. Changes in beta 4 integrin expression and localization in vivo in response to corneal epithelial injury. Stepp, M.A., Zhu, L., Cranfill, R. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  37. Distinct populations of dendritic cells in the normal human donor corneal epithelium. Yamagami, S., Yokoo, S., Usui, T., Yamagami, H., Amano, S., Ebihara, N. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  38. Inhibition of rat corneal angiogenesis by 16-kDa prolactin and by endogenous prolactin-like molecules. Dueñas, Z., Torner, L., Corbacho, A.M., Ochoa, A., Gutiérrez-Ospina, G., López-Barrera, F., Barrios, F.A., Berger, P., Martínez de la Escalera, G., Clapp, C. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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