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Gene Review

ARNT  -  aryl hydrocarbon receptor nuclear...

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Disease relevance of ARNT

  • We further found that cardiovascular helix-loop-helix factor (CHF) 2, which had been identified as an ARNT-interacting protein, was expressed in BAEC and suppressed HRE-dependent gene expression both under normoxia and hypoxia [1].

High impact information on ARNT


Analytical, diagnostic and therapeutic context of ARNT

  • In this study, we examined the subcellular localization of HIF-1alpha and -2alpha in bovine arterial EC (BAEC) by immunoblotting and immunocytostaining analysis and found that even under normoxic conditions, as with its heterodimeric partner ARNT, HIF-2alpha was stable, and was localized in the nucleus of BAEC differently than HIF-1alpha [1].


  1. Subcellular localization and regulation of hypoxia-inducible factor-2alpha in vascular endothelial cells. Takahashi, R., Kobayashi, C., Kondo, Y., Nakatani, Y., Kudo, I., Kunimoto, M., Imura, N., Hara, S. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain. Maemura, K., Hsieh, C.M., Jain, M.K., Fukumoto, S., Layne, M.D., Liu, Y., Kourembanas, S., Yet, S.F., Perrella, M.A., Lee, M.E. J. Biol. Chem. (1999) [Pubmed]
  3. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Dong, W., Teraoka, H., Tsujimoto, Y., Stegeman, J.J., Hiraga, T. Toxicol. Sci. (2004) [Pubmed]
  4. The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements. Klinge, C.M., Bowers, J.L., Kulakosky, P.C., Kamboj, K.K., Swanson, H.I. Mol. Cell. Endocrinol. (1999) [Pubmed]
  5. Nuclear localization of hypoxia-inducible factor-2alpha in bovine arterial endothelial cells. Hara, S., Kobayashi, C., Imura, N. Mol. Cell Biol. Res. Commun. (1999) [Pubmed]
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