Gene Review:
AHR - aryl hydrocarbon receptor
Homo sapiens
Synonyms:
Ah receptor, AhR, Aryl hydrocarbon receptor, BHLHE76, Class E basic helix-loop-helix protein 76, ...
Gustafsson,
Consonni,
Bertazzi,
Klinge,
Khorram,
Dalton,
Bradshaw,
Miller,
Matthews,
Trepel,
Kaur,
Whitlock,
Lucier,
Stevens,
Mocarelli,
Nagy,
Hose,
Needham,
Wihlén,
Garthwaite,
Thomsen,
Landi,
Denison,
Baccarelli,
Nebert,
Loaiza-Pérez,
Caporaso,
Golos,
Sausville,
Trapani,
Yi-Zhou Jiang,
Okey,
Gonzalez,
Singh,
Swanson,
Grassman,
Masten,
- Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. Nebert, D.W., Dalton, T.P., Okey, A.B., Gonzalez, F.J. J. Biol. Chem. (2004)
- Uterine and ovarian aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in benign and malignant gynaecological conditions. Khorram, O., Garthwaite, M., Golos, T. Mol. Hum. Reprod. (2002)
- Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population. Chen, D., Tian, T., Wang, H., Liu, H., Hu, Z., Wang, Y., Liu, Y., Ma, H., Fan, W., Miao, R., Sun, W., Wang, Y., Qian, J., Jin, L., Wei, Q., Shen, H., Huang, W., Lu, D. Pharmacogenet. Genomics (2009)
- Interindividual difference in expression of human Ah receptor and related P450 genes. Hayashi, S., Watanabe, J., Nakachi, K., Eguchi, H., Gotoh, O., Kawajiri, K. Carcinogenesis (1994)
- Regulatory interaction between arylhydrocarbon receptor and SIM1, two basic helix-loop-helix PAS proteins involved in the control of food intake. Yang, C., Boucher, F., Tremblay, A., Michaud, J.L. J. Biol. Chem. (2004)
- Polymorphism of alpha-estrogen receptor and aryl hydrocarbon receptor genes in dementia patients in Shanghai suburb. Lin, G.F., Ma, Q.W., Zhang, D.S., Zha, Y.L., Lou, K.J., Shen, J.H. Acta Pharmacol. Sin. (2003)
- Genetic differences in alcohol drinking preference between inbred strains of mice. He, X.X., Nebert, D.W., Vasiliou, V., Zhu, H., Shertzer, H.G. Pharmacogenetics (1997)
- Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Kuperman, D.A., Huang, X., Koth, L.L., Chang, G.H., Dolganov, G.M., Zhu, Z., Elias, J.A., Sheppard, D., Erle, D.J. Nat. Med. (2002)
- Cloning of a factor required for activity of the Ah (dioxin) receptor. Hoffman, E.C., Reyes, H., Chu, F.F., Sander, F., Conley, L.H., Brooks, B.A., Hankinson, O. Science (1991)
- Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Denison, M.S., Nagy, S.R. Annu. Rev. Pharmacol. Toxicol. (2003)
- Induction of cytochrome P4501A1. Whitlock, J.P. Annu. Rev. Pharmacol. Toxicol. (1999)
- Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Rinaldi, A.L., Morse, M.A., Fields, H.W., Rothas, D.A., Pei, P., Rodrigo, K.A., Renner, R.J., Mallery, S.R. Cancer Res. (2002)
- For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. Dragin, N., Dalton, T.P., Miller, M.L., Shertzer, H.G., Nebert, D.W. J. Biol. Chem. (2006)
- Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Loaiza-Pérez, A.I., Trapani, V., Hose, C., Singh, S.S., Trepel, J.B., Stevens, M.F., Bradshaw, T.D., Sausville, E.A. Mol. Pharmacol. (2002)
- Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. Wormke, M., Castro-Rivera, E., Chen, I., Safe, S. J. Steroid Biochem. Mol. Biol. (2000)
- CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis. Wu, M.L., Li, H., Wu, D.C., Wang, X.W., Chen, X.Y., Kong, Q.Y., Ma, J.X., Gao, Y., Liu, J. Neurosci. Lett. (2005)
- Expression of the human aryl hydrocarbon receptor complex in yeast. Activation of transcription by indole compounds. Miller, C.A. J. Biol. Chem. (1997)
- ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. Beischlag, T.V., Perdew, G.H. J. Biol. Chem. (2005)
- Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Kondraganti, S.R., Fernandez-Salguero, P., Gonzalez, F.J., Ramos, K.S., Jiang, W., Moorthy, B. Int. J. Cancer (2003)
- An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or CYP1A1 genes. Anttila, S., Lei, X.D., Elovaara, E., Karjalainen, A., Sun, W., Vainio, H., Hankinson, O. Pharmacogenetics (2000)
- Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. Li, W., Harper, P.A., Tang, B.K., Okey, A.B. Biochem. Pharmacol. (1998)
- Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters. Matthews, J., Wihlén, B., Thomsen, J., Gustafsson, J.A. Mol. Cell. Biol. (2005)
- TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident. Landi, M.T., Bertazzi, P.A., Baccarelli, A., Consonni, D., Masten, S., Lucier, G., Mocarelli, P., Needham, L., Caporaso, N., Grassman, J. Carcinogenesis (2003)
- Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Ebert, B., Seidel, A., Lampen, A. Carcinogenesis (2005)
- Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. Jiang, Y.Z., Wang, K., Fang, R., Zheng, J. J. Histochem. Cytochem. (2010)
- Effect of transforming growth factor-beta1 on expression of aryl hydrocarbon receptor and genes of Ah gene battery: clues for independent down-regulation in A549 cells. Döhr, O., Sinning, R., Vogel, C., Münzel, P., Abel, J. Mol. Pharmacol. (1997)
- The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Rüegg, J., Swedenborg, E., Wahlström, D., Escande, A., Balaguer, P., Pettersson, K., Pongratz, I. Mol. Endocrinol. (2008)
- Transcriptional regulation of the human NRIP1/RIP140 gene by estrogen is modulated by dioxin signalling. Augereau, P., Badia, E., Fuentes, M., Rabenoelina, F., Corniou, M., Derocq, D., Balaguer, P., Cavailles, V. Mol. Pharmacol. (2006)
- Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential. Kumar, M.B., Perdew, G.H. Gene Expr. (1999)
- The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Klinge, C.M., Kaur, K., Swanson, H.I. Arch. Biochem. Biophys. (2000)
- Is CYP1A1 induction always related to AHR signaling pathway? Delescluse, C., Lemaire, G., de Sousa, G., Rahmani, R. Toxicology (2000)
- HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. Kekatpure, V.D., Dannenberg, A.J., Subbaramaiah, K. J. Biol. Chem. (2009)
- Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription factors. Rowlands, J.C., McEwan, I.J., Gustafsson, J.A. Mol. Pharmacol. (1996)
- Requirement of Aryl Hydrocarbon Receptor Overexpression for CYP1B1 Up-Regulation and Cell Growth in Human Lung Adenocarcinomas. Chang, J.T., Chang, H., Chen, P.H., Lin, S.L., Lin, P. Clin. Cancer Res. (2007)
- Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Smart, J., Daly, A.K. Pharmacogenetics (2000)
- Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Liu, S., Abdelrahim, M., Khan, S., Ariazi, E., Jordan, V.C., Safe, S. Biol. Chem. (2006)
- Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor. de Oliveira, S.K., Hoffmeister, M., Gambaryan, S., Müller-Esterl, W., Guimaraes, J.A., Smolenski, A.P. J. Biol. Chem. (2007)
- Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Beischlag, T.V., Wang, S., Rose, D.W., Torchia, J., Reisz-Porszasz, S., Muhammad, K., Nelson, W.E., Probst, M.R., Rosenfeld, M.G., Hankinson, O. Mol. Cell. Biol. (2002)
- Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. Yueh, M.F., Huang, Y.H., Hiller, A., Chen, S., Nguyen, N., Tukey, R.H. J. Biol. Chem. (2003)
- Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. Kumar, M.B., Tarpey, R.W., Perdew, G.H. J. Biol. Chem. (1999)
- Expression of the aryl hydrocarbon receptor (AhR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) in fetal, benign hyperplastic, and malignant prostate. Kashani, M., Steiner, G., Haitel, A., Schaufler, K., Thalhammer, T., Amann, G., Kramer, G., Marberger, M., Schöller, A. Prostate (1998)