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Gene Review:

CCL8 - chemokine (C-C motif) ligand 8

Bos taurus

Dunphy, J. et al., Hosang, K. et al., Aho, A.D. et al., Proost, P. et al., Wempe, F. et al.

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High impact information on CCL8

Genes that were expressed at significantly higher levels (>1.5-fold; P < 0.05) in tissues from Johne's disease-infected animals relative to noninfected animals included those encoding tumor necrosis factor receptor-associated protein 1 (TRAF1), interleukin-1alpha (IL-1alpha), MCP-2, N-cadherin, and beta1 integrin (CD29) [1].
Compared to bovine MCP-1 and MCP-2, the protein consists of 84% and 53% identical amino acids, respectively [2].
Porcine luteal cells express monocyte chemoattractant protein-2 (MCP-2): analysis by cDNA cloning and northern analysis [3].
A pBluescriptSK-derivative pMCP9 was generated from lambda MCP9 by in vivo excision and was shown to contain an open reading frame (ORF) encoding a protein highly homologous to bovine monocyte chemoattractant protein-2 (MCP-2) [3].
The predicted ovine MCP-2 amino acid sequence shares 92 and 85% identity with bovine and porcine MCP-2, respectively [4].

Biological context of CCL8

The bovine MCP-2 gene consists of three exons separated by two introns [5].

Analytical, diagnostic and therapeutic context of CCL8

Similarly, MCP-2 mRNA was detected by Northern blot analysis at high levels in MAL cells after H. contortus intramammary infusion, and increased in BAL cells and lung tissue in HDME-challenged sheep [4].
MCP-2 mRNA was not detected by Northern blots in whole mammary or abomasal tissue, but Southern blot analysis of RT-PCR products also indicates that MCP-2 mRNA increases in abomasal tissue after challenge with H. contortus [4].

References

Enhanced expression of interleukin-1alpha and tumor necrosis factor receptor-associated protein 1 in ileal tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis. Aho, A.D., McNulty, A.M., Coussens, P.M. Infect. Immun. (2003) [Pubmed]
Purification, sequence analysis, and biological characterization of a second bovine monocyte chemotactic protein-1 (Bo MCP-1B). Proost, P., Wuyts, A., Lenaerts, J.P., Van Damme, J. Biochemistry (1994) [Pubmed]
Porcine luteal cells express monocyte chemoattractant protein-2 (MCP-2): analysis by cDNA cloning and northern analysis. Hosang, K., Knoke, I., Klaudiny, J., Wempe, F., Wuttke, W., Scheit, K.H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
Isolation, characterisation and expression of mRNAs encoding the ovine CC chemokines, monocyte chemoattractant protein (MCP)-1alpha and -2. Dunphy, J., Horvath, A., Barcham, G., Balic, A., Bischof, R., Meeusen, E. Vet. Immunol. Immunopathol. (2001) [Pubmed]
Cloning of the gene for bovine monocyte chemoattractant protein-2. Wempe, F., Hanes, J., Scheit, K.H. DNA Cell Biol. (1994) [Pubmed]

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