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Gene Review

CDH2  -  cadherin 2, type 1, N-cadherin (neuronal)

Bos taurus

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High impact information on CDH2

  • The extracellular domain of dg3 shows 39.4% protein sequence identity with bovine N-cadherin and 28.4% identity with the other major desmosomal glycoprotein, dg1, or desmoglein [1].
  • This showed 43% identity with that of the N terminus of the calcium-dependent cell adhesion molecule, N-cadherin [2].
  • Genes that were expressed at significantly higher levels (>1.5-fold; P < 0.05) in tissues from Johne's disease-infected animals relative to noninfected animals included those encoding tumor necrosis factor receptor-associated protein 1 (TRAF1), interleukin-1alpha (IL-1alpha), MCP-2, N-cadherin, and beta1 integrin (CD29) [3].
  • The GalNAcPTase is known to be associated with the adhesion molecule N-cadherin in embryonic avian retinas and with E-cadherin in mammalian pancreatic islet cells [4].
  • The N-cadherin (N-cad) and Connexin43 (Cx43) expression level of rOB cells cultured with SHya remarkably increased after 2h [5].

Biological context of CDH2


Anatomical context of CDH2

  • A novel function of N-cadherin and Connexin43: marked enhancement of alkaline phosphatase activity in rat calvarial osteoblast exposed to sulfated hyaluronan [5].

Analytical, diagnostic and therapeutic context of CDH2

  • Northern blot analysis with the corresponding cDNA probe showed a wide distribution of bovine N-cadherin among non-neuronal, as well as neuronal tissues, while P-cadherin was most abundant in kidney among all the bovine tissues tested, but was undetectable in placenta [7].


  1. Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin-like desmosomal adhesion molecules with heterogeneous cytoplasmic domains. Collins, J.E., Legan, P.K., Kenny, T.P., MacGarvie, J., Holton, J.L., Garrod, D.R. J. Cell Biol. (1991) [Pubmed]
  2. Desmosomal glycoproteins 2 and 3 (desmocollins) show N-terminal similarity to calcium-dependent cell-cell adhesion molecules. Holton, J.L., Kenny, T.P., Legan, P.K., Collins, J.E., Keen, J.N., Sharma, R., Garrod, D.R. J. Cell. Sci. (1990) [Pubmed]
  3. Enhanced expression of interleukin-1alpha and tumor necrosis factor receptor-associated protein 1 in ileal tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis. Aho, A.D., McNulty, A.M., Coussens, P.M. Infect. Immun. (2003) [Pubmed]
  4. Rod outer segment-associated N-acetylgalactosaminylphosphotransferase. Sweatt, A.J., Balsamo, J., Lilien, J. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  5. A novel function of N-cadherin and Connexin43: marked enhancement of alkaline phosphatase activity in rat calvarial osteoblast exposed to sulfated hyaluronan. Nagahata, M., Tsuchiya, T., Ishiguro, T., Matsuda, N., Nakatsuchi, Y., Teramoto, A., Hachimori, A., Abe, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Enhancement of Borna disease virus transcription in persistently infected cells by serum starvation. Mizutani, T., Inagaki, H., Hayasaka, D., Kariwa, H., Takashima, I. J. Vet. Med. Sci. (1999) [Pubmed]
  7. Identification and cloning of two species of cadherins in bovine endothelial cells. Liaw, C.W., Cannon, C., Power, M.D., Kiboneka, P.K., Rubin, L.L. EMBO J. (1990) [Pubmed]
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