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Gene Review

GRO1  -  chemokine (C-X-C motif) ligand 1 (melanoma...

Bos taurus

Synonyms: CXCL1, MGSA
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Disease relevance of CXCL1

  • Infection of bovine ligated loops with the Salmonella enterica serotype Typhimurium wild type but not a sipA sopABDE2 mutant resulted in fluid accumulation, polymorphonuclear cell infiltration, and expression of CXC chemokines, particularly GRO alpha [1].

High impact information on CXCL1

  • The majority of GRO alpha transcripts localized to bovine intestinal epithelium [1].
  • We found that chemokines MCP-1 and GRO-alpha were upregulated in the CNS of mice with EAE despite the GKO genotype [2].
  • In general, upregulation started 2-4h p.i. and maximum transcript levels were observed 4h p.i. GRO-alpha and IL-8 gene transcription had decreased to almost control levels by 12h p.i.; in the case of the other chemokines enhanced transcript levels persisted longer or showed a biphasic time-course [3].


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