Gene Review:
CXCL2 - chemokine (C-X-C motif) ligand 2
Homo sapiens
Synonyms:
C-X-C motif chemokine 2, CINC-2a, GRO2, GROB, GROb, ...
- Gene expression profiling reveals cross-talk between melanoma and fibroblasts: implications for host-tumor interactions in metastasis. Gallagher, P.G., Bao, Y., Prorock, A., Zigrino, P., Nischt, R., Politi, V., Mauch, C., Dragulev, B., Fox, J.W. Cancer Res. (2005)
- Selective local PMN recruitment by CXCL1 or CXCL2/3 injection does not cause inflammatory pain. Rittner, H.L., Mousa, S.A., Labuz, D., Beschmann, K., Schäfer, M., Stein, C., Brack, A. J. Leukoc. Biol. (2006)
- A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. Flores, C., Maca-Meyer, N., Pérez-Méndez, L., Sangüesa, R., Espinosa, E., Muriel, A., Blanco, J., Villar, J. Genes Immun. (2006)
- Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Tsujimoto, H., Ono, S., Majima, T., Kawarabayashi, N., Takayama, E., Kinoshita, M., Seki, S., Hiraide, H., Moldawer, L.L., Mochizuki, H. Shock (2005)
- Region-specific regulation of inflammation and pathogenesis in experimental autoimmune encephalomyelitis. Archambault, A.S., Sim, J., McCandless, E.E., Klein, R.S., Russell, J.H. J. Neuroimmunol. (2006)
- Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. Yang, J., Luan, J., Yu, Y., Li, C., DePinho, R.A., Chin, L., Richmond, A. Cancer Res. (2001)
- The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Zhao, L., Moos, M.P., Gräbner, R., Pédrono, F., Fan, J., Kaiser, B., John, N., Schmidt, S., Spanbroek, R., Lötzer, K., Huang, L., Cui, J., Rader, D.J., Evans, J.F., Habenicht, A.J., Funk, C.D. Nat. Med. (2004)
- Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. Lotz, M., Gütle, D., Walther, S., Ménard, S., Bogdan, C., Hornef, M.W. J. Exp. Med. (2006)
- Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2. Biedermann, T., Kneilling, M., Mailhammer, R., Maier, K., Sander, C.A., Kollias, G., Kunkel, S.L., Hültner, L., Röcken, M. J. Exp. Med. (2000)
- Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. Tekamp-Olson, P., Gallegos, C., Bauer, D., McClain, J., Sherry, B., Fabre, M., van Deventer, S., Cerami, A. J. Exp. Med. (1990)
- Angiotensin II induces neutrophil accumulation in vivo through generation and release of CXC chemokines. Nabah, Y.N., Mateo, T., Estellés, R., Mata, M., Zagorski, J., Sarau, H., Cortijo, J., Morcillo, E.J., Jose, P.J., Sanz, M.J. Circulation (2004)
- Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury. Hogaboam, C.M., Simpson, K.J., Chensue, S.W., Steinhauser, M.L., Lukacs, N.W., Gauldie, J., Strieter, R.M., Kunkel, S.L. Gene Ther. (1999)
- Differential local and systemic regulation of the murine chemokines KC and MIP2. Call, D.R., Nemzek, J.A., Ebong, S.J., Bolgos, G.R., Newcomb, D.E., Wollenberg, G.K., Remick, D.G. Shock (2001)
- Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. Closa, D., Sabater, L., Fernández-Cruz, L., Prats, N., Gelpí, E., Roselló-Catafau, J. Ann. Surg. (1999)
- Management of neglected giant omphalocele with Gore-tex in a child aged 8 years. Sakellaris, G., Petrakis, I., Vlazakis, S., Kakavelakis, K., Vasiliou, M., Antipas, S., Ntolatzas, T. Minerva Pediatr. (2002)
- Expression of AMPA-type glutamate receptors in HEK cells and cerebellar granule neurons impairs CXCL2-mediated chemotaxis. Limatola, C., Di Bartolomeo, S., Trettel, F., Lauro, C., Ciotti, M.T., Mercanti, D., Castellani, L., Eusebi, F. J. Neuroimmunol. (2003)
- Expression analysis of immune response genes of M??ller cells infected with Toxoplasma gondii. Knight, B.C., Kissane, S., Falciani, F., Salmon, M., Stanford, M.R., Wallace, G.R. J. Neuroimmunol. (2006)
- Chemokine receptor CXCR2 regulates the functional properties of AMPA-type glutamate receptor GluR1 in HEK cells. Lax, P., Limatola, C., Fucile, S., Trettel, F., Di Bartolomeo, S., Renzi, M., Ragozzino, D., Eusebi, F. J. Neuroimmunol. (2002)
- A tumor necrosis factor receptor 1-dependent conversation between central nervous system-specific T cells and the central nervous system is required for inflammatory infiltration of the spinal cord. Gimenez, M.A., Sim, J., Archambault, A.S., Klein, R.S., Russell, J.H. Am. J. Pathol. (2006)
- CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses. Kielian, T., Barry, B., Hickey, W.F. J. Immunol. (2001)
- The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization. Bozic, C.R., Gerard, N.P., von Uexkull-Guldenband, C., Kolakowski, L.F., Conklyn, M.J., Breslow, R., Showell, H.J., Gerard, C. J. Biol. Chem. (1994)
- Pneumocystis carinii cell wall beta-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide-mediated mechanism. Hahn, P.Y., Evans, S.E., Kottom, T.J., Standing, J.E., Pagano, R.E., Limper, A.H. J. Biol. Chem. (2003)
- Lung inflammation in hyperoxia can be prevented by antichemokine treatment in newborn rats. Deng, H., Mason, S.N., Auten, R.L. Am. J. Respir. Crit. Care Med. (2000)
- Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. Estellés, R., Milian, L., Nabah, Y.N., Mateo, T., Cerdá-Nicolás, M., Losada, M., Ivorra, M.D., Issekutz, A.C., Cortijo, J., Morcillo, E.J., Blázquez, M.A., Sanz, M.J. J. Leukoc. Biol. (2005)
- Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mechanism. Gupta, V., Yeo, G., Kawakubo, H., Rangnekar, V., Ramaswamy, P., Hayashida, T., MacLaughlin, D.T., Donahoe, P.K., Maheswaran, S. Cancer Res. (2007)
- Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. Sozzani, S., Luini, W., Borsatti, A., Polentarutti, N., Zhou, D., Piemonti, L., D'Amico, G., Power, C.A., Wells, T.N., Gobbi, M., Allavena, P., Mantovani, A. J. Immunol. (1997)
- Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype. Li, A., Varney, M.L., Singh, R.K. Clin. Exp. Metastasis (2004)
- Pain control by CXCR2 ligands through Ca2+-regulated release of opioid peptides from polymorphonuclear cells. Rittner, H.L., Labuz, D., Schaefer, M., Mousa, S.A., Schulz, S., Sch??fer, M., Stein, C., Brack, A. FASEB J. (2006)
- Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung. Bhandari, V., Elias, J.A. Free Radic. Biol. Med. (2006)
- Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes. Jerva, L.F., Sullivan, G., Lolis, E. Protein Sci. (1997)
- Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats. Schmal, H., Shanley, T.P., Jones, M.L., Friedl, H.P., Ward, P.A. J. Immunol. (1996)
- Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. Taylor, K.R., Trowbridge, J.M., Rudisill, J.A., Termeer, C.C., Simon, J.C., Gallo, R.L. J. Biol. Chem. (2004)