Disease relevance of SEC1

• Functionally, SEC1-stimulated CD4(+) T cells suppressed the proliferation of naive PBMC in response to heat-killed-fixed Staphylococcus aureus [1].

High impact information on SEC1

• Organization of the bovine alpha 2-fucosyltransferase gene cluster suggests that the Sec1 gene might have been shaped through a nonautonomous L1-retrotransposition event within the same locus [2].
• A consequence of this event was the processing in Catarrhini of a Sec1 pseudogene via several point mutations [2].
• An increase in the transcription of IL-10 and transforming growth factor beta (TGF-beta) genes in SEC1-stimulated cultures was attributed to the CD4(+) CD25(+) T-cell subpopulation [1].
• Activation of bovine lymphocytes by either SEC1 or concanavalin A (ConA) was influenced by the gammadelta/alphabeta T-cell ratio in the culture [3].
• Compared to ConA-induced stimulation, cultures stimulated with SEC1 generated small numbers of CD4+ alphabeta T cells expressing high levels of interleukin-2 receptor alpha chain (IL-2R alpha) and major histocompatibility complex class II (MHCII), suggesting that SAg exposure does not lead to full activation of these cells [3].

Biological context of SEC1

• Their open reading frames (ORF) encode polypeptides of 360 (bovine H), 344 (bovine Se), and 368 (bovine Sec1) amino acids, respectively [4].
• The SEC animal variants have greater than 98% amino acid sequence identity with SEC1, a human-associated SEC [5].
• Four other lactating cows received the same strain transformed with the plasmid without the SEC1 gene (positive control), and four cows were untreated (negative control) [6].

Anatomical context of SEC1

• To examine the possible impact of SEC on the immune response of the bovine mammary gland, we monitored changes in lymphocyte subpopulations in mammary glands of four lactating cows after intramammary instillation of S. aureus strain Rn4220 transformed with a plasmid containing a gene coding for SEC1 [6].

Analytical, diagnostic and therapeutic context of SEC1

• To determine if immunosuppression caused by SAgs could play a role in pathogenesis, we monitored bovine lymphocytes exposed to staphylococcal enterotoxin C1 (SEC1) [3].

References