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Gene Review:

ADCY1 - adenylate cyclase 1 (brain)

Bos taurus

Gierschik, P. et al., Heideman, W. et al., Morris, D. et al., Glynn, P. et al., Westcott, K.R. et al., et al.

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High impact information on ADCY1

Antiserum AS/1, which recognized all three subunits (alpha, beta, and gamma) of the holoprotein, was tested for cross-reactivity with the subunits of the adenylyl cyclase [adenylate cyclase; ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1]-associated stimulatory (Ns) and inhibitory (Ni) N proteins purified from human erythrocytes [1].
The importance of guanyl nucleotides for calmodulin stimulation of bovine cerebral cortex adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] was examined by using a partially purified calmodulin-sensitive adenylate cyclase that was resolved from calmodulin-insensitive forms of the enzyme [2].
Partially purified adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] from bovine brain cortex was fractionated into two separate forms by calcium-dependent regulatory protein (CDR)-Sepharose affinity chromatography [3].
Adenylate cyclase [ATP pyrophosphate lyase (cyclizing), EC 4.6.1.1] was shown to be present in cultured human articular chondrocytes [4].
The activation of bovine thyroid adenylate cyclase (ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1) by Gpp(NH)p has been studied using steady-state kinetic methods [5].

Anatomical context of ADCY1

Incubation of bovine adrenocortical membranes with corticotropin and 5-guanylylimidodiphosphate produced a state of adenylate cyclase (ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1) with maximal catalytic activity and an increased sensitivity to inhibition by adenosine [6].

Associations of ADCY1 with chemical compounds

An antibody (RM) raised against the carboxyl-terminal decapeptide of the alpha subunit of the stimulatory guanine nucleotide regulatory protein (Gs alpha) has been used to study the interaction of Gs alpha with bovine brain adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] [7].

References

Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. Gierschik, P., Codina, J., Simons, C., Birnbaumer, L., Spiegel, A. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
GTP is not required for calmodulin stimulation of bovine brain adenylate cyclase. Heideman, W., Wierman, B.M., Storm, D.R. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
Resolution of adenylate cyclase sensitive and insensitive to Ca2+ and calcium-dependent regulatory protein (CDR) by CDR-sepharose affinity chromatography. Westcott, K.R., La Porte, D.C., Storm, D.R. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
Adenylate cyclase of human articular chondrocytes. Responsiveness to prostaglandins and other hormones. Houston, J.P., McGuire, M.K., Meats, J.E., Ebsworth, N.M., Russell, R.G., Crawford, A., Mac Neil, S. Biochem. J. (1982) [Pubmed]
Interactions of fluoride and guanine nucleotides with thyroid adenylate cyclase. Goldhammer, A., Wolff, J. Biochim. Biophys. Acta (1982) [Pubmed]
Inhibition of bovine adrenocortical adenylate cyclase activity by adenosine. Glynn, P., Cooper, D.M. Biochim. Biophys. Acta (1978) [Pubmed]
Immunoprecipitation of adenylate cyclase with an antibody to a carboxyl-terminal peptide from Gs alpha. Morris, D., McHugh-Sutkowski, E., Moos, M., Simonds, W.F., Spiegel, A.M., Seamon, K.B. Biochemistry (1990) [Pubmed]

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