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Gene Review

ICAM3  -  intercellular adhesion molecule 3

Bos taurus

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High impact information on ICAM3

  • The predicted number and positions of Cys residues are all conserved between the bovine and human ICAM 3 aa sequences [1].
  • This putative bovine ICAM-3 has five immunoglobulin (Ig)-like domains similar to human ICAM-1 and ICAM-3, and belongs to the Ig gene superfamily [1].
  • Northern blot results show that the bovine ICAM-1 gene is expressed in stimulated leukocytes whereas bovine ICAM-3 is expressed predominantly in resting neutrophils [2].
  • The predicted number and positions of cysteine residues in bovine ICAM-1 are all conserved among species including bovine ICAM-3 [2].


  1. Cloning and sequencing of a cDNA encoding bovine intercellular adhesion molecule 3 (ICAM-3). Lee, E.K., Kehrli, M.E., Dietz, A.B., Bosworth, B.T., Reinhardt, T.A. Gene (1996) [Pubmed]
  2. Cloning, sequencing and analysis of cDNA encoding bovine intercellular adhesion molecule-1 (ICAM-1). Lee, E., Kang, S.G., Kehrli, M.E. Vet. Immunol. Immunopathol. (1997) [Pubmed]
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