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Gene Review:

PRKCG - protein kinase C, gamma

Bos taurus

Gonzalez, K. et al., Marais, R.M. et al., Husain, S. et al.

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Disease relevance of PRKCG

When the lens epithelial cells were cultured in media supplemented with 40 mM galactose, to model the conditions of sugar cataracts, a decrease in PKC-gamma, but not in PKC-alpha was observed [1].

High impact information on PRKCG

While PKC-alpha and -beta are indistinguishable in their phosphorylation of these peptides, PKC-gamma shows a distinct specificity profile for these synthetic substrates [2].
PKC gamma is equally distributed in cytosol and membrane fractions of bovine, but mostly cytosolic in dog [3].

Anatomical context of PRKCG

Western blots of lens epithelial cell homogenates showed that PKC-alpha antisera reacted with a major protein, and PKC-gamma antisera reacted with a minor protein [1].

References

Protein kinase C in galactosemic and tolrestat-treated lens epithelial cells. Gonzalez, K., Udovichenko, I., Cunnick, J., Takemoto, D.J. Curr. Eye Res. (1993) [Pubmed]
Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates. Marais, R.M., Nguyen, O., Woodgett, J.R., Parker, P.J. FEBS Lett. (1990) [Pubmed]
Protein kinase C isoforms in iris sphincter smooth muscle: differential effects of phorbol ester on contraction and cAMP accumulation are species specific. Husain, S., Abdel-Latif, A.A. Curr. Eye Res. (1996) [Pubmed]

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