Gene Review:
Prkcg - protein kinase C, gamma
Mus musculus
Synonyms:
PKC-gamma, PKCgamma, Pkcc, Pkcg, Prkcc, ...
- Alterations in protein kinase C isozymes alpha and beta 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol. Mills, K.J., Bocckino, S.B., Burns, D.J., Loomis, C.R., Smart, R.C. Carcinogenesis (1992)
- Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain. Gardell, L.R., Ibrahim, M., Wang, R., Wang, Z., Ossipov, M.H., Malan, T.P., Porreca, F., Lai, J. Neuroscience (2004)
- The role of protein kinase C in the regulation of serotonin-2A receptor expression. Anji, A., Sullivan Hanley, N.R., Kumari, M., Hensler, J.G. J. Neurochem. (2001)
- Differential staining of neurons in the human retina with antibodies to protein kinase C isozymes. Kolb, H., Zhang, L., Dekorver, L. Vis. Neurosci. (1993)
- Protein kinase C gamma (PKC gamma): function of neuron specific isotype. Saito, N., Shirai, Y. J. Biochem. (2002)
- Alterations of protein kinase C isozyme and substrate proteins in mouse brain after electroconvulsive seizures. Chen, C.C. Brain Res. (1994)
- Changes in PKC gamma immunoreactivity in mouse hippocampus induced by spatial discrimination learning. Van der Zee, E.A., Compaan, J.C., de Boer, M., Luiten, P.G. J. Neurosci. (1992)
- Impaired synapse elimination during cerebellar development in PKC gamma mutant mice. Kano, M., Hashimoto, K., Chen, C., Abeliovich, A., Aiba, A., Kurihara, H., Watanabe, M., Inoue, Y., Tonegawa, S. Cell (1995)
- Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Abeliovich, A., Chen, C., Goda, Y., Silva, A.J., Stevens, C.F., Tonegawa, S. Cell (1993)
- Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Malmberg, A.B., Chen, C., Tonegawa, S., Basbaum, A.I. Science (1997)
- Alterations in the immunoreactivity for muscarinic acetylcholine receptors and colocalized PKC gamma in mouse hippocampus induced by spatial discrimination learning. Van der Zee, E.A., Compaan, J.C., Bohus, B., Luiten, P.G. Hippocampus. (1995)
- Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCgamma null mutant mice. Bowers, B.J., Elliott, K.J., Wehner, J.M. Pharmacol. Biochem. Behav. (2001)
- Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme. Bowers, B.J., Parham, C.L., Sikela, J.M., Wehner, J.M. Gene (1993)
- Functional characterization of the promoter region of the mouse protein kinase C gamma gene. Takanaga, H., Mukai, H., Shimakawa, M., Konishi, H., Kikkawa, U., Koizumi, T., Ono, Y. FEBS Lett. (1995)
- Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla. Narita, M., Mizoguchi, H., Khotib, J., Suzuki, M., Ozaki, S., Yajima, Y., Narita, M., Tseng, L.F., Suzuki, T. Neurosci. Lett. (2002)
- Mice lacking PKC gamma exhibit decreased anxiety. Bowers, B.J., Collins, A.C., Tritto, T., Wehner, J.M. Behav. Genet. (2000)
- Generation and characterization of the PKCgamma-Cre mouse line. Ding, Y.Q., Xiang, C.X., Chen, Z.F. Genesis (2005)
- Altered trafficking of membrane proteins in purkinje cells of SCA1 transgenic mice. Skinner, P.J., Vierra-Green, C.A., Clark, H.B., Zoghbi, H.Y., Orr, H.T. Am. J. Pathol. (2001)
- Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization. Avazeri, N., Courtot, A.M., Lefevre, B. J. Cell. Sci. (2004)
- Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters. Wang, X.J., Warren, B.S., Rupp, T., Beltrán, L.M., DiGiovanni, J. Carcinogenesis (1994)
- Mutant mice lacking the gamma isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of gamma-aminobutyrate type A receptors. Harris, R.A., McQuilkin, S.J., Paylor, R., Abeliovich, A., Tonegawa, S., Wehner, J.M. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Characterization of conventional protein kinase C (PKC) isotype expression during F9 teratocarcinoma differentiation. Overexpression of PKC alpha alters the expression of some differentiation-dependent genes. Kindregan, H.C., Rosenbaum, S.E., Ohno, S., Niles, R.M. J. Biol. Chem. (1994)
- Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice. Zeitz, K.P., Malmberg, A.B., Gilbert, H., Basbaum, A.I. Pain (2001)
- Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex. Jardemark, K.E., Ninan, I., Liang, X., Wang, R.Y. Neuroscience (2003)
- Ethanol consumption and behavioral impulsivity are increased in protein kinase Cgamma null mutant mice. Bowers, B.J., Wehner, J.M. J. Neurosci. (2001)
- Different regulation of Purkinje cell dendritic development in cerebellar slice cultures by protein kinase Calpha and -beta. Gundlfinger, A., Kapfhammer, J.P., Kruse, F., Leitges, M., Metzger, F. J. Neurobiol. (2003)
- Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo. Mazzoni, E., Adam, A., Bal de Kier Joffe, E., Aguirre-Ghiso, J.A. Mol. Cancer Res. (2003)
- Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development. Balasubramanian, G., Amann, J.F., Reddy, C.S. J. Craniofac. Genet. Dev. Biol. (2000)
- Expression of protein kinase C gene family members is temporally and spatially regulated during neural development in vitro. Oehrlein, S.A., Maelicke, A., Herget, T. Eur. J. Cell Biol. (1998)
- Central glucocorticoid receptors modulate the expression and function of spinal NMDA receptors after peripheral nerve injury. Wang, S., Lim, G., Zeng, Q., Sung, B., Yang, L., Mao, J. J. Neurosci. (2005)
- Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cgamma gene. Célérier, E., Simonnet, G., Maldonado, R. Neuropharmacology (2004)
- Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice. Shutoh, F., Katoh, A., Ohki, M., Itohara, S., Tonegawa, S., Nagao, S. Eur. J. Neurosci. (2003)
- Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice. McNamara, R.K., Lenox, R.H. Neurosci. Lett. (2004)
- Pentylenetetrazole-induced chemoshock affects protein kinase C and substrate proteins in mouse brain. Chen, C.C. J. Neurochem. (1994)
- Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. Kumar, S., Sieghart, W., Morrow, A.L. J. Neurochem. (2002)