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Gene Review

TYRP1  -  tyrosinase-related protein 1

Bos taurus

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High impact information on TYRP1

  • The inhibitory activity of WnLRFa (IC50 = 40 microM) is lost when either the NH2-terminal amino group is acylated or the NH2-terminal Trp1 is deleted [1].
  • Predicted proteins encoded by bovine TYR, TYRP1 and DCT display high levels of homology and contain all characteristic domains shared between their mouse and human counterparts [2].
  • Tyrosinase related protein 1 (TYRP1), which is involved in the coat colour pathway, was mapped to BTA8 between microsatellites BL1080 and BM4006, using a microsatellite in intron 5 of TYRP1 [3].
  • To find molecular markers for Prim'Holstein's milk detection in RDO cheese, four genes affecting coat color in cattle (c-kit, MGH, TYRP1, and MC1R) have been sequenced for three mountain breeds and the Prim'Holstein breed [4].

Analytical, diagnostic and therapeutic context of TYRP1

  • In addition, full-sib families of beef cattle generated by embryo transfer and half-sib families from traditional matings in which coat colour was segregating were used to correlate TYRP1 sequence variants with dilute coat colours [3].


  1. Phe-Met-Arg-Phe-NH2 (FMRFa)-related peptides inhibit Na(+)-Ca2+ exchange in cardiac sarcolemma vesicles. Khananshvili, D., Price, D.C., Greenberg, M.J., Sarne, Y. J. Biol. Chem. (1993) [Pubmed]
  2. Pheomelanin coat colour dilution in French cattle breeds is not correlated with the TYR, TYRP1 and DCT transcription levels. Guibert, S., Girardot, M., Leveziel, H., Julien, R., Oulmouden, A. Pigment Cell Res. (2004) [Pubmed]
  3. TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow? Berryere, T.G., Schmutz, S.M., Schimpf, R.J., Cowan, C.M., Potter, J. Anim. Genet. (2003) [Pubmed]
  4. Holstein's milk detection in cheeses inferred from melanocortin receptor 1 (MC1R) gene polymorphism. Maudet, C., Taberlet, P. J. Dairy Sci. (2002) [Pubmed]
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