The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

DCT  -  dopachrome tautomerase

Bos taurus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of DCT

  • Control of clinical mastitis and BTSCC involves a range of management practices that need to be used in conjunction with DCT [1].
 

High impact information on DCT

  • It is proposed that PTH influences Ca++ reabsorption by the DCT because the target molecule, the Na+/Ca++ exchanger, is located exclusively at this site [2].
  • Predicted proteins encoded by bovine TYR, TYRP1 and DCT display high levels of homology and contain all characteristic domains shared between their mouse and human counterparts [3].
  • Tyrosinase-related protein-2 (DCT; TYRP2) maps to bovine chromosome 12 [4].
  • It also offers an ideal opportunity to improve udder health, through the judicious use of antibiotics to treat high SCC cows.The prophylactic use of antibiotics in food producing animals is increasingly being called into question; DCT is the primary example of such antibiotic use in the dairy cow [5].
  • Aim: To evaluate associations between management decisions related to the control of mastitis, including the infusion of antibiotics at the end of lactation (dry-cow therapy; DCT), on the incidence of clinical mastitis over the non-lactating period and the bulk tank somatic cell count (BTSCC) in the subsequent lactation [1].
 

Biological context of DCT

  • From an udder-health perspective, the goal of the dry period can be met by recommending administration of DCT to all quarters of all cows at the end of lactation [6].
 

Other interactions of DCT

  • Incubation of DCT suspension with 10(-8) M bovine PTH (1-34) resulted in a significant increase in the Na(+)-dependent Ca++ uptake by the corresponding BLM vesicles [2].
 

Analytical, diagnostic and therapeutic context of DCT

  • An SNP in DCT is used for linkage mapping on cattle chromosome 12 [7].
  • Reduced BTSCC was also associated with smaller herds, use of partial (compared with full depth) insertion of the DCT cannula, not reducing feed intake at the time of drying off, checking for clinical mastitis over the dry (non-lactation) period in the milking parlour, and use of udder shape for diagnosis during lactation [1].

References

  1. Management factors associated with the incidence of clinical mastitis over the non-lactation period and bulk tank somatic cell count during the subsequent lactation. McDougall, S. New Zealand veterinary journal. (2003) [Pubmed]
  2. The mechanism of parathyroid hormone action on calcium reabsorption by the distal tubule. Bouhtiauy, I., Lajeunesse, D., Brunette, M.G. Endocrinology (1991) [Pubmed]
  3. Pheomelanin coat colour dilution in French cattle breeds is not correlated with the TYR, TYRP1 and DCT transcription levels. Guibert, S., Girardot, M., Leveziel, H., Julien, R., Oulmouden, A. Pigment Cell Res. (2004) [Pubmed]
  4. Tyrosinase-related protein-2 (DCT; TYRP2) maps to bovine chromosome 12. Hawkins, G.A., Eggen, A., Hayes, H., Elduque, C., Bishop, M.D. Mamm. Genome (1996) [Pubmed]
  5. The importance of the nonlactating period in the epidemiology of intramammary infection and strategies for prevention. Bradley, A.J., Green, M.J. Vet. Clin. North Am. Food Anim. Pract. (2004) [Pubmed]
  6. Management of the dry cow in control of peripartum disease and mastitis. Dingwell, R.T., Kelton, D.F., Leslie, K.E. Vet. Clin. North Am. Food Anim. Pract. (2003) [Pubmed]
  7. An SNP in DCT is used for linkage mapping on cattle chromosome 12. Schmutz, S.M., Berryere, T.G., Buchanan, F.C. Anim. Genet. (2000) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities