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Gene Review

KIT  -  v-kit Hardy-Zuckerman 4 feline sarcoma...

Bos taurus

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Disease relevance of KIT

  • The current study investigates the potential role of the growth factor kit ligand (KL)/stem cell growth factor and its receptor c-kit in normal OSE biology and ovarian cancer [1].

High impact information on KIT

  • No differences were observed in the steady state levels of c-kit messenger RNA in theca cells from small, medium, or large size follicles [2].
  • Occasionally, large round colonies consisting of single, c-kit-negative, type A spermatogonia (presumably spermatogonial stem cells) were observed [3].
  • Most of the cells in these colonies underwent differentiation because they were c-kit positive, and ultimately, cells with morphological and molecular characteristics of spermatocytes and spermatids were formed [3].
  • Sequence of a bovine c-kit proto-oncogene cDNA [4].
  • Free c-kit-positive cells in an intravasal position are common, suggesting separation from the clusters in order to colonize subsequent hematopoietic organs, i.e., the liver and the mesonephros [5].

Biological context of KIT

  • The present findings suggested that the activation of gammadelta T cells via c-kit receptor participated in the suppressed expression of cytokine mRNA in T cells during lactation period [6].

Anatomical context of KIT

  • Human tumors from borderline, stage I, and stage III cases of ovarian cancer were found to express KL and c-kit protein in the epithelial cell component by ICC analysis [1].
  • Nearly all of the large type A spermatogonia showed strong c-kit immunoreactivity, indicating that these cells had undergone at least an initial differentiation step [7].
  • Interestingly, c-kit mRNA was exclusively expressed in gammadelta T cells [6].

Other interactions of KIT

  • To find molecular markers for Prim'Holstein's milk detection in RDO cheese, four genes affecting coat color in cattle (c-kit, MGH, TYRP1, and MC1R) have been sequenced for three mountain breeds and the Prim'Holstein breed [8].


  1. Expression and action of kit ligand/stem cell factor in normal human and bovine ovarian surface epithelium and ovarian cancer. Parrott, J.A., Kim, G., Skinner, M.K. Biol. Reprod. (2000) [Pubmed]
  2. Direct actions of kit-ligand on theca cell growth and differentiation during follicle development. Parrott, J.A., Skinner, M.K. Endocrinology (1997) [Pubmed]
  3. Proliferation and differentiation of bovine type A spermatogonia during long-term culture. Izadyar, F., Den Ouden, K., Creemers, L.B., Posthuma, G., Parvinen, M., De Rooij, D.G. Biol. Reprod. (2003) [Pubmed]
  4. Sequence of a bovine c-kit proto-oncogene cDNA. Kubota, T., Hikono, H., Sasaki, E., Sakurai, M. Gene (1994) [Pubmed]
  5. Immunophenotyping and spatio-temporal distribution of aortic cell clusters in the bovine embryo. Kritzenberger, M., Wrobel, K.H. Anat. Embryol. (2006) [Pubmed]
  6. Differential gene expression of cytokine and cell surface molecules in T cell subpopulation derived from mammary gland secretion of cows. Asai, K., Yamaguchi, T., Kuroishi, T., Komine, Y., Kai, K., Komine, K., Kumagai, K. Am. J. Reprod. Immunol. (2003) [Pubmed]
  7. Isolation and purification of type A spermatogonia from the bovine testis. Izadyar, F., Spierenberg, G.T., Creemers, L.B., den Ouden, K., de Rooij, D.G. Reproduction (2002) [Pubmed]
  8. Holstein's milk detection in cheeses inferred from melanocortin receptor 1 (MC1R) gene polymorphism. Maudet, C., Taberlet, P. J. Dairy Sci. (2002) [Pubmed]
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