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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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SLC2A5  -  solute carrier family 2 (facilitated...

Bos taurus

 
 
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High impact information on SLC2A5

  • Notably, the currents were desensitized, reduced in a glucose concentration-dependent manner, and markedly inhibited by either a second application of glucose or the addition of glucose to the patch electrode filling solution; they were potentiated, however, by treatment with cytochalasin B, a GLUT1 to GLUT5 inhibitor [1].
  • On the other side, transcripts from genes related with metabolism, growth, and differentiation (Glut-5, Cx 43, IGF-II, and IGF-IR) were detected in higher amounts in in vivo produced embryos and in embryos with fast developmental speed [2].
  • Transcript levels for mitochondrial Mn-superoxide dismutase (MnSOD), survivin, and glucose transport 5 (Glut-5) were significantly higher in ovine blastocysts than bovine (P < 0.05), while transcripts for Connexin 31 (Cx31), interferon tau (IFN-tau), and sarcosine oxidase (SOX) were significantly more abundant in bovine blastocysts (P < 0.01) [3].
  • RESULTS: Group 2 showed a 44% increase in galactose absorption (P < 0.01) and a 14% increase in GLUT-5 band intensity (P < 0.05), but no change in DNA content or SGLT band intensity [4].
  • We were able to detect small quantities of GLUT 3 in fetal liver and of GLUT 5 in postnatal liver [5].

References

  1. Low glucose enhances Na+/glucose transport in bovine brain artery endothelial cells. Nishizaki, T., Matsuoka, T. Stroke (1998) [Pubmed]
  2. Effect of speed of development on mRNA expression pattern in early bovine embryos cultured in vivo or in vitro. Gutiérrez-Adán, A., Rizos, D., Fair, T., Moreira, P.N., Pintado, B., de la Fuente, J., Boland, M.P., Lonergan, P. Mol. Reprod. Dev. (2004) [Pubmed]
  3. Species-related differences in blastocyst quality are associated with differences in relative mRNA transcription. Rizos, D., Gutierrez-Adan, A., Moreira, P., O'Meara, C., Fair, T., Evans, A.C., Boland, M.P., Lonergan, P. Mol. Reprod. Dev. (2004) [Pubmed]
  4. Novel effect of leptin on small intestine adaptation. Pearson, P.Y., O'Connor, D.M., Schwartz, M.Z. J. Surg. Res. (2001) [Pubmed]
  5. Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction. Lane, R.H., Flozak, A.S., Simmons, R.A. Biochem. Mol. Med. (1996) [Pubmed]
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