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Gene Review

SLC2A3  -  solute carrier family 2 (facilitated...

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High impact information on SLC2A3


Biological context of SLC2A3

  • The gestational decline in relative contribution of GLUT-1 to cytochalasin binding, together with the greater developmental increases in GLUT-3 mRNA and protein, further suggests that the relative importance of GLUT-3 increases with gestational age [4].

Anatomical context of SLC2A3


Associations of SLC2A3 with chemical compounds


Other interactions of SLC2A3

  • Glut1, Glut3, Glut8, and SGLT-I were expressed in all stages studied [8].
  • We were able to detect small quantities of GLUT 3 in fetal liver and of GLUT 5 in postnatal liver [9].


  1. Characterization of the avian GLUT1 glucose transporter: differential regulation of GLUT1 and GLUT3 in chicken embryo fibroblasts. Wagstaff, P., Kang, H.Y., Mylott, D., Robbins, P.J., White, M.K. Mol. Biol. Cell (1995) [Pubmed]
  2. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-alpha, but not by insulin. Pekala, P., Marlow, M., Heuvelman, D., Connolly, D. J. Biol. Chem. (1990) [Pubmed]
  3. Regulation of glucose transporter (GLUT 3) and aldose reductase mRNA inbovine retinal endothelial cells and retinal pericytes in high glucose and high galactose culture. Knott, R.M., Robertson, M., Forrester, J.V. Diabetologia (1993) [Pubmed]
  4. Developmental increases in glucose transporter concentration in the sheep placenta. Ehrhardt, R.A., Bell, A.W. Am. J. Physiol. (1997) [Pubmed]
  5. Distinct regulation of glucose transport and GLUT1/GLUT3 transporters by glucose deprivation and IGF-I in chromaffin cells. Fladeby, C., Skar, R., Serck-Hanssen, G. Biochim. Biophys. Acta (2003) [Pubmed]
  6. High glucose downregulates glucose transport activity in retinal capillary pericytes but not endothelial cells. Mandarino, L.J., Finlayson, J., Hassell, J.R. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  7. A sodium- and energy-dependent glucose transporter with similarities to SGLT1-2 is expressed in bovine cortical vessels. Nishizaki, T., Kammesheidt, A., Sumikawa, K., Asada, T., Okada, Y. Neurosci. Res. (1995) [Pubmed]
  8. Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos. Augustin, R., Pocar, P., Navarrete-Santos, A., Wrenzycki, C., Gandolfi, F., Niemann, H., Fischer, B. Mol. Reprod. Dev. (2001) [Pubmed]
  9. Measurement of GLUT mRNA in liver of fetal and neonatal rats using a novel method of quantitative polymerase chain reaction. Lane, R.H., Flozak, A.S., Simmons, R.A. Biochem. Mol. Med. (1996) [Pubmed]
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