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Gene Review

SLC2A5  -  solute carrier family 2 (facilitated...

Homo sapiens

Synonyms: Fructose transporter, GLUT-5, GLUT5, Glucose transporter type 5, small intestine, Solute carrier family 2, facilitated glucose transporter member 5
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Disease relevance of SLC2A5


High impact information on SLC2A5


Chemical compound and disease context of SLC2A5


Biological context of SLC2A5


Anatomical context of SLC2A5


Associations of SLC2A5 with chemical compounds


Physical interactions of SLC2A5


Regulatory relationships of SLC2A5

  • Immunohistochemical study revealed that the GLUT5 protein expressed was localized at apical membranes and that the GLUT1 expressed was present primarily in the basolateral membranes of cells grown on permeable support [4].
  • Fructose-induced changes in FBPase activity may regulate changes in GLUT5 expression and activity in the small intestine of neonatal rats [18].

Other interactions of SLC2A5


Analytical, diagnostic and therapeutic context of SLC2A5


  1. Expression of the fructose transporter GLUT5 in human breast cancer. Zamora-León, S.P., Golde, D.W., Concha, I.I., Rivas, C.I., Delgado-López, F., Baselga, J., Nualart, F., Vera, J.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. Godoy, A., Ulloa, V., Rodríguez, F., Reinicke, K., Yañez, A.J., García, M.d.e. .L., Medina, R.A., Carrasco, M., Barberis, S., Castro, T., Martínez, F., Koch, X., Vera, J.C., Poblete, M.T., Figueroa, C.D., Peruzzo, B., Pérez, F., Nualart, F. J. Cell. Physiol. (2006) [Pubmed]
  3. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. Mahraoui, L., Takeda, J., Mesonero, J., Chantret, I., Dussaulx, E., Bell, G.I., Brot-Laroche, E. Biochem. J. (1994) [Pubmed]
  4. Targeting of GLUT1-GLUT5 chimeric proteins in the polarized cell line Caco-2. Inukai, K., Takata, K., Asano, T., Katagiri, H., Ishihara, H., Nakazaki, M., Fukushima, Y., Yazaki, Y., Kikuchi, M., Oka, Y. Mol. Endocrinol. (1997) [Pubmed]
  5. Evaluation of fluorodeoxyglucose-positron emission tomographic scanning and its association with glucose transporter expression in medullary thyroid carcinoma and pheochromocytoma: a clinical and molecular study. Musholt, T.J., Musholt, P.B., Dehdashti, F., Moley, J.F. Surgery (1997) [Pubmed]
  6. Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption. Wasserman, D., Hoekstra, J.H., Tolia, V., Taylor, C.J., Kirschner, B.S., Takeda, J., Bell, G.I., Taub, R., Rand, E.B. J. Clin. Invest. (1996) [Pubmed]
  7. Inhibition of cell proliferation in human breast tumor cells by antisense oligonucleotides against facilitative glucose transporter 5. Chan, K.K., Chan, J.Y., Chung, K.K., Fung, K.P. J. Cell. Biochem. (2004) [Pubmed]
  8. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). Kayano, T., Burant, C.F., Fukumoto, H., Gould, G.W., Fan, Y.S., Eddy, R.L., Byers, M.G., Shows, T.B., Seino, S., Bell, G.I. J. Biol. Chem. (1990) [Pubmed]
  9. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Gouyon, F., Onesto, C., Dalet, V., Pages, G., Leturque, A., Brot-Laroche, E. Biochem. J. (2003) [Pubmed]
  10. Fructose transporter in human spermatozoa and small intestine is GLUT5. Burant, C.F., Takeda, J., Brot-Laroche, E., Bell, G.I., Davidson, N.O. J. Biol. Chem. (1992) [Pubmed]
  11. Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Kurata, T., Oguri, T., Isobe, T., Ishioka, S., Yamakido, M. Jpn. J. Cancer Res. (1999) [Pubmed]
  12. Facilitative glucose transporters. Mueckler, M. Eur. J. Biochem. (1994) [Pubmed]
  13. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Richardson, S., Neama, G., Phillips, T., Bell, S., Carter, S.D., Moley, K.H., Moley, J.F., Vannucci, S.J., Mobasheri, A. Osteoarthr. Cartil. (2003) [Pubmed]
  14. Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation. Fu, Y., Maianu, L., Melbert, B.R., Garvey, W.T. Blood Cells Mol. Dis. (2004) [Pubmed]
  15. Human intestinal glucose transporter expression and localization of GLUT5. Davidson, N.O., Hausman, A.M., Ifkovits, C.A., Buse, J.B., Gould, G.W., Burant, C.F., Bell, G.I. Am. J. Physiol. (1992) [Pubmed]
  16. Overexpression of GLUT5 in Diabetic Muscle Is Reversed by Pioglitazone. Stuart, C.A., Howell, M.E., Yin, D. Diabetes Care (2007) [Pubmed]
  17. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. Scheepers, A., Schmidt, S., Manolescu, A., Cheeseman, C.I., Bell, A., Zahn, C., Joost, H.G., Schürmann, A. Mol. Membr. Biol. (2005) [Pubmed]
  18. Vanadate but not tungstate prevents the fructose-induced increase in GLUT5 expression and fructose uptake by neonatal rat intestine. Kirchner, S., Kwon, E., Muduli, A., Cerqueira, C., Cui, X.L., Ferraris, R.P. J. Nutr. (2006) [Pubmed]
  19. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. Stuart, C.A., Yin, D., Howell, M.E., Dykes, R.J., Laffan, J.J., Ferrando, A.A. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  20. Intracellular organization of insulin signaling and GLUT4 translocation. Watson, R.T., Pessin, J.E. Recent Prog. Horm. Res. (2001) [Pubmed]
  21. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. White, P.S., Jensen, S.J., Rajalingam, V., Stairs, D., Sulman, E.P., Maris, J.M., Biegel, J.A., Wooster, R., Brodeur, G.M. Cytogenet. Cell Genet. (1998) [Pubmed]
  22. Human erythrocytes express GLUT5 and transport fructose. Concha, I.I., Velásquez, F.V., Martínez, J.M., Angulo, C., Droppelmann, A., Reyes, A.M., Slebe, J.C., Vera, J.C., Golde, D.W. Blood (1997) [Pubmed]
  23. Expression of monosaccharide transporters in intestine of diabetic humans. Dyer, J., Wood, I.S., Palejwala, A., Ellis, A., Shirazi-Beechey, S.P. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
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