The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Slc2a5  -  solute carrier family 2 (facilitated...

Mus musculus

Synonyms: AI526984, Fructose transporter, GLUT-5, GLUT5, Glucose transporter type 5, small intestine, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Slc2a5

  • GLUT5 was estimated to contribute to 100 % of total uptake in wild-type mice fed low-sugar diets, falling to 60 and 40 % with glucose and fructose diets respectively; the complement was ensured by GLUT2 activity [1].
  • Fructose uptake in brush-border membrane vesicles from GLUT2-null mice was half that of wild-type mice and was similar to the cytochalasin B-insensitive component, i.e. GLUT5-mediated uptake [1].
  • Northern and Western blot analyses and immunohistochemistry were used to determine the abundance of sodium-independent glucose and fructose transporters (GLUT)2 and GLUT5 [2].
  • Using stringent controls, clear expression of glut5 and khk was localized to Purkinje cells in the cerebellum [3].
  • Only three of the nine transcripts analysed (Glut 5, Gpx 1 and Igf2bp1) were significantly down-regulated at blastocyst stage in in vitro produced controls [4].

Anatomical context of Slc2a5

  • Northern blot studies detected GLUT5 mRNA expression in mouse small intestine, kidney, and testis, with transcript sizes of approximately 2.1, 2.1, and 2.8 kb, respectively [5].
  • In addition, developmental studies showed a significant increase in GLUT5 mRNA expression levels in adult mouse testis when compared to prepubertal mouse testis [5].
  • 5'Rapid Amplification of cDNA Ends (5'RACE) determined that the differences in transcript sizes occurred because GLUT5 possessed alternative transcriptional initiation sites in somatic and germ cells [5].
  • Expression of mouse GLUT5 cRNA in Xenopus laevis oocytes showed that GLUT5 mediated fructose transport, with a K(t) of 13 mM [5].
  • Expression of GLUT5 in chondrocytes suggests that fructose is also used as an energy source [6].

Associations of Slc2a5 with chemical compounds

  • In agreement with studies in rats and rabbits, mouse small intestinal GLUT5 mRNA expression levels were increased following exposure to a 65% fructose-enriched diet [5].
  • Neither GLUT3 nor GLUT5 appeared to account for insulin-stimulated glucose-transport activity in wild-type or GLUT4-null muscle [7].
  • As confirmed by transepithelial potential difference (PD) measurements, there is a distinct fructose transporter that does not evoke a PD, along with one or more aldohexose transporters that do evoke a PD [8].

Analytical, diagnostic and therapeutic context of Slc2a5


  1. Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. Gouyon, F., Caillaud, L., Carriere, V., Klein, C., Dalet, V., Citadelle, D., Kellett, G.L., Thorens, B., Leturque, A., Brot-Laroche, E. J. Physiol. (Lond.) (2003) [Pubmed]
  2. Dietary lipids modify the age-associated changes in intestinal uptake of fructose in rats. Drozdowski, L., Woudstra, T., Wild, G., Clandinin, M.T., Thomson, A.B. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  3. Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum. Funari, V.A., Herrera, V.L., Freeman, D., Tolan, D.R. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  4. Differential effects of culture and nuclear transfer on relative transcript levels of genes with key roles during preimplantation. Moreira, P.N., Fernández-Gonzalez, R., Ramirez, M.A., Pérez-Crespo, M., Rizos, D., Pintado, B., Gutiérrez-Adán, A. Zygote (2006) [Pubmed]
  5. Cloning and functional characterization of the mouse fructose transporter, GLUT5. Corpe, C.P., Bovelander, F.J., Munoz, C.M., Hoekstra, J.H., Simpson, I.A., Kwon, O., Levine, M., Burant, C.F. Biochim. Biophys. Acta (2002) [Pubmed]
  6. Immunocytochemical demonstration of glucose transporters in epiphyseal growth plate chondrocytes of young rats in correlation with autoradiographic distribution of 2-deoxyglucose in chondrocytes of mice. Ohara, H., Tamayama, T., Maemura, K., Kanbara, K., Hayasaki, H., Abe, M., Watanabe, M. Acta Histochem. (2001) [Pubmed]
  7. In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle. Ryder, J.W., Kawano, Y., Chibalin, A.V., Rincón, J., Tsao, T.S., Stenbit, A.E., Combatsiaris, T., Yang, J., Holman, G.D., Charron, M.J., Zierath, J.R. Biochem. J. (1999) [Pubmed]
  8. Comparison of different dietary sugars as inducers of intestinal sugar transporters. Solberg, D.H., Diamond, J.M. Am. J. Physiol. (1987) [Pubmed]
  9. Effects of changes in calorie intake on intestinal nutrient uptake and transporter mRNA levels in aged mice. Casirola, D.M., Lan, Y., Ferraris, R.P. J. Gerontol. A Biol. Sci. Med. Sci. (1997) [Pubmed]
  10. Immunohistochemical localization of facilitated-diffusion glucose transporters in rat pancreatic islets. Sato, Y., Ito, T., Udaka, N., Kanisawa, M., Noguchi, Y., Cushman, S.W., Satoh, S. Tissue & cell. (1996) [Pubmed]
WikiGenes - Universities