The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ADAMTS5  -  ADAM metallopeptidase with thrombospondin...

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ADAMTS5

  • RESULTS: ADAMTS-4, but not ADAMTS-5, was induced in human chondrocytes infected with B burgdorferi [1].
  • Matrix molecules showed little change in expression after injurious compression, whereas MMP-3 increased approximately 250-fold, ADAMTS-5 increased approximately 40-fold, and tissue inhibitor of metalloproteinases 1 increased approximately 12-fold above the levels in free swelling cultures [2].
  • The expression of ADAM-TS4, ADAM-TS5, and MMP-13 was abrogated by the inclusion of 10 microM CSA in the culture medium [3].
  • In particular, ADAMTS-1, -2, -3, -4, -5 (also known as ADAMTS-11), -7, -8, and -9, but not ADAMTS-6, -10, or -12, mRNA transcripts were detected in granulosa cells of nonatretic ovarian follicles and corpora lutea [4].
  • RESULTS: Both aggrecanase-1 and aggrecanase-2 are able to cleave bovine and human biglycan at a site within their central leucine-rich repeat regions [5].

Other interactions of ADAMTS5

  • IL-1 treatment increased mRNA abundance for ADAMTS4 ( approximately 3-fold) and ADAMTS5 ( approximately 10-fold) but this was not accompanied by a marked change in enzyme protein abundance [6].


  1. Role of aggrecanase 1 in Lyme arthritis. Behera, A.K., Hildebrand, E., Szafranski, J., Hung, H.H., Grodzinsky, A.J., Lafyatis, R., Koch, A.E., Kalish, R., Perides, G., Steere, A.C., Hu, L.T. Arthritis Rheum. (2006) [Pubmed]
  2. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Lee, J.H., Fitzgerald, J.B., Dimicco, M.A., Grodzinsky, A.J. Arthritis Rheum. (2005) [Pubmed]
  3. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Little, C.B., Hughes, C.E., Curtis, C.L., Jones, S.A., Caterson, B., Flannery, C.R. Arthritis Rheum. (2002) [Pubmed]
  4. Expression of messenger RNA for ADAMTS subtypes changes in the periovulatory follicle after the gonadotropin surge and during luteal development and regression in cattle. Madan, P., Bridges, P.J., Komar, C.M., Beristain, A.G., Rajamahendran, R., Fortune, J.E., MacCalman, C.D. Biol. Reprod. (2003) [Pubmed]
  5. The cleavage of biglycan by aggrecanases. Melching, L.I., Fisher, W.D., Lee, E.R., Mort, J.S., Roughley, P.J. Osteoarthr. Cartil. (2006) [Pubmed]
  6. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Patwari, P., Gao, G., Lee, J.H., Grodzinsky, A.J., Sandy, J.D. Osteoarthr. Cartil. (2005) [Pubmed]
WikiGenes - Universities