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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ADAMTS5  -  ADAM metallopeptidase with thrombospondin...

Bos taurus

 
 
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High impact information on ADAMTS5

  • RESULTS: ADAMTS-4, but not ADAMTS-5, was induced in human chondrocytes infected with B burgdorferi [1].
  • Matrix molecules showed little change in expression after injurious compression, whereas MMP-3 increased approximately 250-fold, ADAMTS-5 increased approximately 40-fold, and tissue inhibitor of metalloproteinases 1 increased approximately 12-fold above the levels in free swelling cultures [2].
  • The expression of ADAM-TS4, ADAM-TS5, and MMP-13 was abrogated by the inclusion of 10 microM CSA in the culture medium [3].
  • In particular, ADAMTS-1, -2, -3, -4, -5 (also known as ADAMTS-11), -7, -8, and -9, but not ADAMTS-6, -10, or -12, mRNA transcripts were detected in granulosa cells of nonatretic ovarian follicles and corpora lutea [4].
  • RESULTS: Both aggrecanase-1 and aggrecanase-2 are able to cleave bovine and human biglycan at a site within their central leucine-rich repeat regions [5].
 

Other interactions of ADAMTS5

  • IL-1 treatment increased mRNA abundance for ADAMTS4 ( approximately 3-fold) and ADAMTS5 ( approximately 10-fold) but this was not accompanied by a marked change in enzyme protein abundance [6].

References

  1. Role of aggrecanase 1 in Lyme arthritis. Behera, A.K., Hildebrand, E., Szafranski, J., Hung, H.H., Grodzinsky, A.J., Lafyatis, R., Koch, A.E., Kalish, R., Perides, G., Steere, A.C., Hu, L.T. Arthritis Rheum. (2006) [Pubmed]
  2. Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Lee, J.H., Fitzgerald, J.B., Dimicco, M.A., Grodzinsky, A.J. Arthritis Rheum. (2005) [Pubmed]
  3. Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Little, C.B., Hughes, C.E., Curtis, C.L., Jones, S.A., Caterson, B., Flannery, C.R. Arthritis Rheum. (2002) [Pubmed]
  4. Expression of messenger RNA for ADAMTS subtypes changes in the periovulatory follicle after the gonadotropin surge and during luteal development and regression in cattle. Madan, P., Bridges, P.J., Komar, C.M., Beristain, A.G., Rajamahendran, R., Fortune, J.E., MacCalman, C.D. Biol. Reprod. (2003) [Pubmed]
  5. The cleavage of biglycan by aggrecanases. Melching, L.I., Fisher, W.D., Lee, E.R., Mort, J.S., Roughley, P.J. Osteoarthr. Cartil. (2006) [Pubmed]
  6. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Patwari, P., Gao, G., Lee, J.H., Grodzinsky, A.J., Sandy, J.D. Osteoarthr. Cartil. (2005) [Pubmed]
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