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Gene Review

Adamts5  -  a disintegrin-like and metallopeptidase...

Mus musculus

Synonyms: 9530092O11Rik, A disintegrin and metalloproteinase with thrombospondin motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, ...
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Disease relevance of Adamts5

  • In mice with nutritionally induced obesity (high fat diet) as well as in lean controls, aggrecan mRNA expression was downregulated whereas ADAMTS-4 and ADAMTS-5 were upregulated with time [1].

High impact information on Adamts5

  • Here we show that despite ablation of ADAMTS-5 activity, aggrecanolysis can still occur at two preferred sites in the chondroitin sulfate-rich region [2].
  • ADAMTS-5, but not ADAMTS-1, -4, or -9, was up-regulated 8-fold by retinoic acid and 17-fold by IL-1alpha treatment [2].
  • ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan [2].
  • RESULTS: ADAMTS-4, but not ADAMTS-5, was induced in human chondrocytes infected with B burgdorferi [3].
  • There was no difference in mRNA levels in the cartilage of WT compared with KO mice for the other potential aggrecanases ADAMTS-4, ADAMTS-5, or ADAMTS-9 [4].

Biological context of Adamts5


Anatomical context of Adamts5


Associations of Adamts5 with chemical compounds

  • Retinoic acid was more effective than interleukin-1alpha (IL) in promoting cleavage at these sites in ADAMTS-5-deficient cartilage [2].
  • In expanded COCs and differentiated granulosa cells, FSH induced expression of ADAMTS4 and versican message and protein, whereas increased levels of ADAMTS1 protein was observed in the media of granulosa cells where it was stabilized by heparin in this in vitro system [5].

Other interactions of Adamts5

  • Stimulation by IL-1 results in the increased expression of catabolic effectors including MMP-13, nitric oxide synthase, ADAMTS4, and ADAMTS5 [9].

Analytical, diagnostic and therapeutic context of Adamts5

  • To determine whether other family members might be expressed and regulated in the rodent ovary, those closely related to ADAMTS1 (ADAMTS4 and ADAMTS5) were analyzed in the mouse ovary by reverse transcription-polymerase chain reaction as well as by Western blot, immunohistochemical, and immunocytochemical analyses using highly specific antibodies [5].


  1. Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development. Voros, G., Sandy, J.D., Collen, D., Lijnen, H.R. Biochim. Biophys. Acta (2006) [Pubmed]
  2. ADAMTS-5 Deficiency Does Not Block Aggrecanolysis at Preferred Cleavage Sites in the Chondroitin Sulfate-rich Region of Aggrecan. East, C.J., Stanton, H., Golub, S.B., Rogerson, F.M., Fosang, A.J. J. Biol. Chem. (2007) [Pubmed]
  3. Role of aggrecanase 1 in Lyme arthritis. Behera, A.K., Hildebrand, E., Szafranski, J., Hung, H.H., Grodzinsky, A.J., Lafyatis, R., Koch, A.E., Kalish, R., Perides, G., Steere, A.C., Hu, L.T. Arthritis Rheum. (2006) [Pubmed]
  4. ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Little, C.B., Mittaz, L., Belluoccio, D., Rogerson, F.M., Campbell, I.K., Meeker, C.T., Bateman, J.F., Pritchard, M.A., Fosang, A.J. Arthritis Rheum. (2005) [Pubmed]
  5. Regulated expression of ADAMTS family members in follicles and cumulus oocyte complexes: evidence for specific and redundant patterns during ovulation. Richards, J.S., Hernandez-Gonzalez, I., Gonzalez-Robayna, I., Teuling, E., Lo, Y., Boerboom, D., Falender, A.E., Doyle, K.H., LeBaron, R.G., Thompson, V., Sandy, J.D. Biol. Reprod. (2005) [Pubmed]
  6. Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression. Wang, K., Vishwanath, P., Eichler, G.S., Al-Sebaei, M.O., Edgar, C.M., Einhorn, T.A., Smith, T.F., Gerstenfeld, L.C. Matrix Biol. (2006) [Pubmed]
  7. Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis. Brown, H.M., Dunning, K.R., Robker, R.L., Pritchard, M., Russell, D.L. Dev. Biol. (2006) [Pubmed]
  8. Expression of ADAMTS-5/implantin in human decidual stromal cells: regulatory effects of cytokines. Zhu, H., Leung, P.C., Maccalman, C.D. Hum. Reprod. (2007) [Pubmed]
  9. Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype. Majumdar, M.K., Chockalingam, P.S., Bhat, R.A., Sheldon, R., Keohan, C., Blanchet, T., Glasson, S., Morris, E.A. J. Cell. Physiol. (2006) [Pubmed]
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