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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Wfdc2  -  WAP four-disulfide core domain 2

Rattus norvegicus

Synonyms: Epididymal secretory protein 4, RE4, WAP four-disulfide core domain protein 2
 
 
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Disease relevance of Wfdc2

  • The phototoxicity of liposome-incorporated Zn(II)-phthalocyanine (ZnPc) and its water-soluble tetrasulphonated derivative (ZnPcTS) was studied in the tumorigenic but nonmetastatic (RE4) and the highly metastatic (4R) transformed rat embryo fibroblasts [1].
 

High impact information on Wfdc2

  • The RE4 allele is 18 kilobases long and contains six exons and five introns, whereas the RE5 allele contains an additional approximately 8 kilobases of intron sequences and an extra exon encoding a 5'-untranslated region; however, the APOBEC-1 transcripts from the two alleles appear to have similar, if not identical, functions [2].
  • In contrast, low-expressing RE4 mice had normal liver function and histology and did not develop liver tumors when examined at 3 to 17 months of age [3].
  • RE4 APOBEC-1 transgenic mice should prove valuable for studying the roles of apoB-containing lipoproteins in lipid metabolism and atherosclerosis [3].
  • A highly metastatic (4R) and a nonmetastatic (RE4) transformed rat embryo fibroblast cell line were incubated with lipid-soluble Zn(II)-phthalocyanine (ZnPc) and its water-soluble tetrasulphonated derivative (ZnPcTS) and compared for phthalocyanine uptake [4].

References

  1. Photosensitization of cells with different metastatic potentials by liposome-delivered Zn(II)-phthalocyanine. Valduga, G., Reddi, E., Garbisa, S., Jori, G. Int. J. Cancer (1998) [Pubmed]
  2. Two distinct TATA-less promoters direct tissue-specific expression of the rat apo-B editing catalytic polypeptide 1 gene. Qian, X., Balestra, M.E., Innerarity, T.L. J. Biol. Chem. (1997) [Pubmed]
  3. Low expression of the apolipoprotein B mRNA-editing transgene in mice reduces LDL levels but does not cause liver dysplasia or tumors. Qian, X., Balestra, M.E., Yamanaka, S., Borén, J., Lee, I., Innerarity, T.L. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  4. Interaction of hydro- or lipophilic phthalocyanines with cells of different metastatic potential. Valduga, G., Bianco, G., Csik, G., Reddi, E., Masiero, L., Garbisa, S., Jori, G. Biochem. Pharmacol. (1996) [Pubmed]
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