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Gene Review: 

IGLV2-8  -  immunoglobulin lambda variable 2-8

Homo sapiens

Synonyms: IGLV28, V1-2
 
 
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Disease relevance of IGLV2-8

  • ST-segment elevation of 0.1 mV or more in leads V1-2 or a VL predicted proximal stenosis of at lest 80% in the left anterior descending coronary artery in all six women with typical angina pectoris [1].
  • Sensitivity was determined using 25 patients with evolutionary ST-T wave changes (V1-2), and LDH and CPK isoenzyme evidence of acute myocardial infarction; and 21 patients with anterior wall akinesia or dyskinesia and greater than 70% occlusion of the left anterior descending coronary artery [2].
  • Mice were immunized with recombinant vaccinia viruses expressing either the wild-type or the variable loop-deleted (V1-2, V3, V4, and V1-3) HIV-1(DH12) gp160s [3].
  • Electrocardiograms showing transmural inferior or anterolateral infarction nearly always indicated coronary disease, while QS patterns in Leads V1-2 occurred frequently with normal coronary arteries [4].
  • Her electrocardiogram (ECG) showed tall R waves in leads V1-2, and ST segment depression in leads V1- 4, consistent with an isolated posterior myocardial infarction (MI) [5].
 

High impact information on IGLV2-8

  • The PKC isoforms inhibitors investigated were V1-2 peptide, GO-6976, rottlerin, and LY-333531 for PKC-epsilon, -alpha, -delta and -beta, respectively [6].
  • For the wild-type gp120, the immunogenic epitopes mapped primarily to the variable loops V1-2 and to the conserved regions C1 and C5 [3].
  • The phenylephrine effect was inhibited by the alpha(1)-adrenoceptor antagonist prazosin (n=4, P<0.05) and by an xi PKC peptide antagonist (xi V1-2) coupled to a TAT peptide (n=5, P<0. 05) [7].
  • In patients presenting with inferior AMI, the presence of ST-depression in the leads aVL and V1-2 is a sensitive finding that indicates Cx stenosis rather than RCA stenosis and is not affected by coexisting other coronary artery involvements [8].
  • The markers used for LLR were: V1-2 peak Latency (the latency between the V1 and V2 peaks); V2 peak-P24 Latency (the latency between the V2 peak and P24 of a somatosensory evoked potential); V2 Amplitude, and V2 Square (the area of the V2 wave) [9].
 

Anatomical context of IGLV2-8

  • The purpose of the study was to assess the frequency of infarction of the posterior wall of the left ventricle which shows a high R wave in leads V1-2 on electrocardiogram [10].
 

Analytical, diagnostic and therapeutic context of IGLV2-8

  • Use of an artificial neural network to analyse an ECG with QS complex in V1-2 leads [11].

References

  1. Diagnostic accuracy of exercise ECG lead systems in clinical subsets of women. Guiteras, P., Chaitman, B.R., Waters, D.D., Bourassa, M.G., Scholl, J.M., Ferguson, R.J., Wagniart, P. Circulation (1982) [Pubmed]
  2. Vectorcardiographic criteria for the diagnosis of anterior myocardial infarction. Starr, J.W., Wagner, G.S., Draffin, R.M., Reed, J.B., Walston, A., Behar, V.S. Circulation (1976) [Pubmed]
  3. Immunogenicity and ability of variable loop-deleted human immunodeficiency virus type 1 envelope glycoproteins to elicit neutralizing antibodies. Kim, Y.B., Han, D.P., Cao, C., Cho, M.W. Virology (2003) [Pubmed]
  4. Aortic stenosis, angina pectoris, and coronary artery disease. Hancock, E.W. Am. Heart J. (1977) [Pubmed]
  5. Electrocardiographical case. An elderly lady with chest pain. Diagnosis: isolated posterior myocardial infarct (MI). Chiam, P., Chuah, S.C., Wong, P., Teo, W.S. Singapore medical journal. (2006) [Pubmed]
  6. PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium. Hassouna, A., Matata, B.M., Galiñanes, M. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  7. Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase. Karliner, J.S., Honbo, N., Epstein, C.J., Xian, M., Lau, Y.F., Gray, M.O. J. Mol. Cell. Cardiol. (2000) [Pubmed]
  8. Differentiating the infarct-related artery on initial electrocardiogram in single or multi-vessel disease in acute inferior myocardial infarction and evaluating involvement of vessels using correspondence analysis. Kürüm, T., Birsin, A., Ozbay, G., Türe, M. Angiology. (2005) [Pubmed]
  9. The long loop reflex in spinocerebellar degeneration and motor neuron disease--its changes with TRH therapy. Touge, T., Takeuchi, H., Yamada, A., Miki, H., Nishioka, M. Electromyography and clinical neurophysiology. (1990) [Pubmed]
  10. Electrocardiogram of posterior wall infarction. Kedra, M., Widomska-Czekajska, T., Sawa, J. Cor et vasa. (1975) [Pubmed]
  11. Use of an artificial neural network to analyse an ECG with QS complex in V1-2 leads. Ouyang, N., Ikeda, M., Yamauchi, K. Medical & biological engineering & computing. (1997) [Pubmed]
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