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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

THYN1  -  thymocyte nuclear protein 1

Homo sapiens

Synonyms: HSPC144, MDS012, MY105, My0054, THY28, ...
 
 
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Disease relevance of THYN1

 

High impact information on THYN1

  • (1)H, (13)C and (15)N backbone resonance assignments of the DUF589 domain from human HSPC144 protein [2].
  • To identify the endonuclease that is responsible for the specific pattern of DNA degradation in glucocorticoid-induced apoptosis, we have developed an assay to measure internucleosomal cleavage activity in thymocyte nuclear extracts [3].
  • HSPC144 is a newly identified gene in human CD34(+) hematopoietic stem/progenitor cells [4].
  • Thus, the anti-IgM-induced down-regulation of the nuclear Thy28 expression appears to correlate with the induction of apoptosis in Ramos B lymphoma cells [1].
  • The Thy28 protein was mainly located in the nucleus, which was revealed by immunofluorescence microscopy and Western blotting using anti-mThy28 Ab, and transient expression of the mThy28/EGFP fusion gene [1].
 

Biological context of THYN1

  • Engagement of membrane immunoglobulin with anti-IgM induced down-regulation of human Thy28 expression at both mRNA and protein levels, accompanied by induction of apoptosis in Ramos B lymphoma cells [1].

References

  1. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. Jiang, X.Z., Toyota, H., Yoshimoto, T., Takada, E., Asakura, H., Mizuguchi, J. Apoptosis (2003) [Pubmed]
  2. (1)H, (13)C and (15)N backbone resonance assignments of the DUF589 domain from human HSPC144 protein. Shi, Y.H., Song, A.X., Chang, Y.G., Hu, H.Y., Lin, D.H. J. Biomol. NMR (2006) [Pubmed]
  3. Internucleosomal deoxyribonucleic acid cleavage activity in apoptotic thymocytes: detection and endocrine regulation. Schwartzman, R.A., Cidlowski, J.A. Endocrinology (1991) [Pubmed]
  4. Identification, expression, and purification of a unique stable domain from human HSPC144 protein. Song, A.X., Chang, Y.G., Gao, Y.G., Lin, X.J., Shi, Y.H., Lin, D.H., Hang, Q.H., Hu, H.Y. Protein Expr. Purif. (2005) [Pubmed]
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