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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sperm Maturation

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Disease relevance of Sperm Maturation


High impact information on Sperm Maturation


Biological context of Sperm Maturation


Anatomical context of Sperm Maturation

  • The N-terminal and mucin-like domains were absent from zonadhesin that bound to the egg extracellular matrix, suggesting that processing occurs during sperm maturation and/or capacitation [15].
  • In addition, these findings demonstrate that late-stage spermatids are transcriptionally active and suggest that the RHL-1 receptor may have a functional role in sperm maturation and/or fertilization [16].
  • No CGRP-RCP immunoreactivity was observed in other cells at less mature stages of sperm maturation, in Sertoli or interstitial (Leydig) cells, or in human spermatozoa [17].
  • To explain the extensive epididymal abnormalities in the Hexb-/- mice, we propose that substrates for Hex, such as testis-derived glycolipids, cannot be catabolized and accumulate in lysosomes, leading to epididymal dysfunction and abnormalities in the epididymal luminal environment that supports sperm maturation [18].
  • Prostaglandins (PGE2, PGF2 alpha) in the excurrent ducts of the male reproductive tract appear to be both modulators of ductal contractility for transport of spermatozoa and factors involved in the regulation of sperm maturation [19].

Associations of Sperm Maturation with chemical compounds


Gene context of Sperm Maturation


Analytical, diagnostic and therapeutic context of Sperm Maturation


  1. Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. Hughes, J., Ward, C.J., Aspinwall, R., Butler, R., Harris, P.C. Hum. Mol. Genet. (1999) [Pubmed]
  2. Reversible male infertility due to sulphasalazine: studies in man and rat. O'Moráin, C., Smethurst, P., Doré, C.J., Levi, A.J. Gut (1984) [Pubmed]
  3. Effects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats. Srikanth, V., Malini, T., Arunakaran, J., Govindarajulu, P., Balasubramanian, K. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  4. Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein. Ruz, R., Gregory, M., Smith, C.E., Cyr, D.G., Lubahn, D.B., Hess, R.A., Hermo, L. Mol. Reprod. Dev. (2006) [Pubmed]
  5. Downregulation of clusterin expression in testicular germ cell tumours. Behrens, P., Jeske, W., Wernert, N., Wellmann, A. Pathobiology (2001) [Pubmed]
  6. Acidification of the male reproductive tract by a proton pumping (H+)-ATPase. Breton, S., Smith, P.J., Lui, B., Brown, D. Nat. Med. (1996) [Pubmed]
  7. Dual function of the selenoprotein PHGPx during sperm maturation. Ursini, F., Heim, S., Kiess, M., Maiorino, M., Roveri, A., Wissing, J., Flohé, L. Science (1999) [Pubmed]
  8. Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1. Keilhack, H., Müller, M., Böhmer, S.A., Frank, C., Weidner, K.M., Birchmeier, W., Ligensa, T., Berndt, A., Kosmehl, H., Günther, B., Müller, T., Birchmeier, C., Böhmer, F.D. J. Cell Biol. (2001) [Pubmed]
  9. Localization of cellular retinol-binding protein in several rat tissues. Porter, S.B., Fraker, L.D., Chytil, F., Ong, D.E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  10. Localization of cholesteryl sulfate in human spermatozoa in support of a hypothesis for the mechanism of capacitation. Langlais, J., Zollinger, M., Plante, L., Chapdelaine, A., Bleau, G., Roberts, K.D. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  11. Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function? Gelissen, I.C., Hochgrebe, T., Wilson, M.R., Easterbrook-Smith, S.B., Jessup, W., Dean, R.T., Brown, A.J. Biochem. J. (1998) [Pubmed]
  12. Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2. Hickox, D.M., Gibbs, G., Morrison, J.R., Sebire, K., Edgar, K., Keah, H.H., Alter, K., Loveland, K.L., Hearn, M.T., de Kretser, D.M., O'Bryan, M.K. Biol. Reprod. (2002) [Pubmed]
  13. Ubiquitin C-terminal hydrolase L-1 is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis. Kwon, J., Mochida, K., Wang, Y.L., Sekiguchi, S., Sankai, T., Aoki, S., Ogura, A., Yoshikawa, Y., Wada, K. Biol. Reprod. (2005) [Pubmed]
  14. Isolation and characterization of a 25-kilodalton protein from mouse testis: sequence homology with a phospholipid-binding protein. Araki, Y., Vierula, M.E., Rankin, T.L., Tulsiani, D.R., Orgebin-Crist, M.C. Biol. Reprod. (1992) [Pubmed]
  15. A sperm membrane protein that binds in a species-specific manner to the egg extracellular matrix is homologous to von Willebrand factor. Hardy, D.M., Garbers, D.L. J. Biol. Chem. (1995) [Pubmed]
  16. Late-stage spermatids are characterized by expression of the "liver-specific" asialoglycoprotein receptor, RHL-1. Huber, B.E. Mol. Pharmacol. (1992) [Pubmed]
  17. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein. Balkan, W., Oates, E.L., Howard, G.A., Roos, B.A. Endocrinology (1999) [Pubmed]
  18. Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides. Trasler, J., Saberi, F., Somani, I.H., Adamali, H.I., Huang, J.Q., Fortunato, S.R., Ritter, G., Gu, M., Aebersold, R., Gravel, R.A., Hermo, L. Endocrinology (1998) [Pubmed]
  19. Immunohistochemical localization of prostaglandin H synthase in the epididymis and vas deferens of the mouse. Marshburn, P.B., Clark, M.R., Shabanowitz, R.B. Biol. Reprod. (1989) [Pubmed]
  20. Temporal association of protamine 1 with the inner nuclear membrane protein lamin B receptor during spermiogenesis. Mylonis, I., Drosou, V., Brancorsini, S., Nikolakaki, E., Sassone-Corsi, P., Giannakouros, T. J. Biol. Chem. (2004) [Pubmed]
  21. Purification and crystallization of a retinoic acid-binding protein from rat epididymis. Identity with the major androgen-dependent epididymal proteins. Newcomer, M.E., Ong, D.E. J. Biol. Chem. (1990) [Pubmed]
  22. Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. Enomoto, A., Wempe, M.F., Tsuchida, H., Shin, H.J., Cha, S.H., Anzai, N., Goto, A., Sakamoto, A., Niwa, T., Kanai, Y., Anders, M.W., Endou, H. J. Biol. Chem. (2002) [Pubmed]
  23. Testosterone and some of its precursors and metabolites in the human epididymis. Leinonen, P., Hammond, G.L., Vihko, R. J. Clin. Endocrinol. Metab. (1980) [Pubmed]
  24. Expression, characterization and engineered specificity of rat epididymal retinoic acid-binding protein. Sundaram, M., Sivaprasadarao, A., Aalten, D.M., Findlay, J.B. Biochem. J. (1998) [Pubmed]
  25. Epididymal SPAM1 Is a Marker for Sperm Maturation in the Mouse. Chen, H., Griffiths, G., Galileo, D.S., Martin-Deleon, P.A. Biol. Reprod. (2006) [Pubmed]
  26. The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha) gene, are localized on mouse chromosome 5. Nishimura, H., Kim, E., Fujimori, T., Kashiwabara, S., Kuroiwa, A., Matsuda, Y., Baba, T. Gene (2002) [Pubmed]
  27. Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule. Mizuki, N., Kasahara, M. Mol. Cell. Endocrinol. (1992) [Pubmed]
  28. Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. Wagenfeld, A., Yeung, C.H., Lehnert, W., Nieschlag, E., Cooper, T.G. J. Androl. (2002) [Pubmed]
  29. Expression of transforming growth factor-beta isoforms in the rat male accessory sex organs and epididymis. Desai, K.V., Flanders, K.C., Kondaiah, P. Cell Tissue Res. (1998) [Pubmed]
  30. Androgen-regulated genes in the murine epididymis. Chauvin, T.R., Griswold, M.D. Biol. Reprod. (2004) [Pubmed]
  31. Zonadhesin assembly into the hamster sperm acrosomal matrix occurs by distinct targeting strategies during spermiogenesis and maturation in the epididymis. Olson, G.E., Winfrey, V.P., Bi, M., Hardy, D.M., NagDas, S.K. Biol. Reprod. (2004) [Pubmed]
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