The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pitx3  -  paired-like homeodomain 3

Rattus norvegicus

Synonyms: Homeobox protein PITX3, Paired-like homeodomain transcription factor 3, Pituitary homeobox 3, Ptx3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pitx3

  • We have identified a bicoid-related homeobox gene, Ptx3, a member of the Ptx-subfamily, that is uniquely expressed in these neurons [1].
  • Adult rat-derived hippocampal progenitor cells express many of the molecules implicated in midbrain dopaminergic determination, including FGF receptors 1, 2 and 3, the sonic hedgehog receptor components Smo and Ptc, and the region-specific transcription factors Ptx3 and Nurr1 [2].
  • The transcription factor Pitx3 is expressed selectively in the midbrain and regulates the differentiation and survival of dopaminergic neurons [3].
  • We report Pitx3 expression in almost all dopaminergic substantia nigra (SN) and ventral tegmental area (VTA) neurons [3].

Other interactions of Pitx3


Analytical, diagnostic and therapeutic context of Pitx3

  • The level of Pitx3 mRNA, determined by semiquantitative RT-PCR, is approximately 6x higher in VTA than in SN single neurons [3].
  • The number of Ptx3-expressing neurons is reduced in Parkinson patients, and these neurons are absent from 6-hydroxydopamine-lesioned rats, an animal model for this disease [1].


  1. A homeodomain gene Ptx3 has highly restricted brain expression in mesencephalic dopaminergic neurons. Smidt, M.P., van Schaick, H.S., Lanctôt, C., Tremblay, J.J., Cox, J.J., van der Kleij, A.A., Wolterink, G., Drouin, J., Burbach, J.P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Sakurada, K., Ohshima-Sakurada, M., Palmer, T.D., Gage, F.H. Development (1999) [Pubmed]
  3. Differential expression of the homeobox gene Pitx3 in midbrain dopaminergic neurons. Korotkova, T.M., Ponomarenko, A.A., Haas, H.L., Sergeeva, O.A. Eur. J. Neurosci. (2005) [Pubmed]
WikiGenes - Universities