The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Ventral Tegmental Area

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Ventral Tegmental Area

 

Psychiatry related information on Ventral Tegmental Area

 

High impact information on Ventral Tegmental Area

 

Chemical compound and disease context of Ventral Tegmental Area

 

Biological context of Ventral Tegmental Area

 

Anatomical context of Ventral Tegmental Area

 

Associations of Ventral Tegmental Area with chemical compounds

  • The cortex receives widespread projections from dopamine neurons in the ventral tegmental area (VTA), which are activated by new stimuli or unpredicted rewards, and are believed to provide a reinforcement signal for such learning-related cortical reorganization [31].
  • This system participates in the primary rewarding effects of cannabinoids, nicotine, alcohol and opioids, through the release of endocannabinoids in the ventral tegmental area [32].
  • We propose that DARPP-32 mediated blunting of the response to ethanol subsequent to activation of ventral tegmental area dopaminergic neurons initiates molecular alterations that influence synaptic plasticity in this circuit, thereby promoting the development of ethanol reinforcement [33].
  • Here we found that the coupling efficacy (EC(50)) of G-protein-gated inwardly rectifying potassium (GIRK, Kir3) channels to GABA(B) receptor was much lower in dopamine neurons than in GABA neurons of the ventral tegmental area (VTA), depending on the differential expression of GIRK subunits [34].
  • Although the cocaine-induced enhancements of both morphine CPP and U69593 CPA followed different time courses, suggesting different mechanisms, both effects were blocked by injection of the N-methyl-d-aspartate receptor antagonist MK-801 (0.5 nmol bilaterally) into the ventral tegmental area, immediately before the cocaine injection [35].
 

Gene context of Ventral Tegmental Area

 

Analytical, diagnostic and therapeutic context of Ventral Tegmental Area

References

  1. Dopamine neuron agenesis in Nurr1-deficient mice. Zetterström, R.H., Solomin, L., Jansson, L., Hoffer, B.J., Olson, L., Perlmann, T. Science (1997) [Pubmed]
  2. Astrocytic basic fibroblast growth factor expression in dopaminergic regions after perinatal anoxia. Flores, C., Stewart, J., Salmaso, N., Zhang, Y., Boksa, P. Biol. Psychiatry (2002) [Pubmed]
  3. Hypotension-induced dopamine release in prefrontal cortex is mediated by local glutamatergic projections at the level of nerve terminals. Kawahara, Y., Kawahara, H., Westerink, B.H. J. Neurochem. (2002) [Pubmed]
  4. 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors. Frye, C.A., Rhodes, M.E., Petralia, S.M., Walf, A.A., Sumida, K., Edinger, K.L. Neuroscience (2006) [Pubmed]
  5. Inhibition by pertussis toxin of the soporific effects induced by stimulation of dopamine D2 autoreceptors in the ventral tegmental area in rats. Bagetta, G., de Sarro, G.B., Priolo, E., Marra, R., Nisticò, G. Neuropharmacology (1989) [Pubmed]
  6. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Eison, A.S., Iversen, S.D., Sandberg, B.E., Watson, S.P., Hanley, M.R., Iversen, L.L. Science (1982) [Pubmed]
  7. Neurobiology of the structure of personality: dopamine, facilitation of incentive motivation, and extraversion. Depue, R.A., Collins, P.F. The Behavioral and brain sciences. (1999) [Pubmed]
  8. The role of dopamine in intracranial self-stimulation of the ventral tegmental area. Fibiger, H.C., LePiane, F.G., Jakubovic, A., Phillips, A.G. J. Neurosci. (1987) [Pubmed]
  9. Sensorimotor impairment and elevated levels of dopamine metabolites in the neostriatum occur rapidly after intranigral injection of 6-hydroxydopamine or gamma-hydroxybutyrate in awake rats. Altar, C.A., O'Neil, S., Marshall, J.F. Neuropharmacology (1984) [Pubmed]
  10. Dopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age. Mann, D.M., Yates, P.O., Marcyniuk, B. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  11. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Ji, S.P., Zhang, Y., Van Cleemput, J., Jiang, W., Liao, M., Li, L., Wan, Q., Backstrom, J.R., Zhang, X. Nat. Med. (2006) [Pubmed]
  12. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Taheri, S., Zeitzer, J.M., Mignot, E. Annu. Rev. Neurosci. (2002) [Pubmed]
  13. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Ungless, M.A., Whistler, J.L., Malenka, R.C., Bonci, A. Nature (2001) [Pubmed]
  14. Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones. Bannon, M.J., Elliott, P.J., Alpert, J.E., Goedert, M., Iversen, S.D., Iversen, L.L. Nature (1983) [Pubmed]
  15. Sensitization to morphine induced by viral-mediated gene transfer. Carlezon, W.A., Boundy, V.A., Haile, C.N., Lane, S.B., Kalb, R.G., Neve, R.L., Nestler, E.J. Science (1997) [Pubmed]
  16. CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus. Bahi, A., Boyer, F., Kafri, T., Dreyer, J.L. Eur. J. Neurosci. (2004) [Pubmed]
  17. Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward. Panagis, G., Kastellakis, A., Spyraki, C., Nomikos, G. Psychopharmacology (Berl.) (2000) [Pubmed]
  18. Autoregulation and monoamine interactions in the ventral tegmental area in the absence and presence of cocaine: a microdialysis study in freely moving rats. Chen, N.H., Reith, M.E. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  19. Correlation between the discharge rate of non-dopamine neurons in substantia nigra and ventral tegmental area and the motor activity induced by apomorphine. Olds, M.E. Neuroscience (1988) [Pubmed]
  20. Locomotor activity in rats after administration of nicotinic agonists intracerebrally. Reavill, C., Stolerman, I.P. Br. J. Pharmacol. (1990) [Pubmed]
  21. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. Mantyh, P.W., Gates, T., Mantyh, C.R., Maggio, J.E. J. Neurosci. (1989) [Pubmed]
  22. Chemical stimulation of the ventral hippocampus elevates nucleus accumbens dopamine by activating dopaminergic neurons of the ventral tegmental area. Legault, M., Rompré, P.P., Wise, R.A. J. Neurosci. (2000) [Pubmed]
  23. Regulation of NMDA receptor subunits and nitric oxide synthase expression during cocaine withdrawal. Loftis, J.M., Janowsky, A. J. Neurochem. (2000) [Pubmed]
  24. Morphine and cocaine exert common chronic actions on tyrosine hydroxylase in dopaminergic brain reward regions. Beitner-Johnson, D., Nestler, E.J. J. Neurochem. (1991) [Pubmed]
  25. Stimulation of the ventral tegmental area enhances the effect of vasopressin on blood pressure in conscious rats. van Den Buuse, M., Catanzariti, R. Br. J. Pharmacol. (2000) [Pubmed]
  26. The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction? Bonci, A., Bernardi, G., Grillner, P., Mercuri, N.B. Trends Pharmacol. Sci. (2003) [Pubmed]
  27. Differential autoreceptor control of somatodendritic and axon terminal dopamine release in substantia nigra, ventral tegmental area, and striatum. Cragg, S.J., Greenfield, S.A. J. Neurosci. (1997) [Pubmed]
  28. Ultrastructural localization of the vesicular monoamine transporter-2 in midbrain dopaminergic neurons: potential sites for somatodendritic storage and release of dopamine. Nirenberg, M.J., Chan, J., Liu, Y., Edwards, R.H., Pickel, V.M. J. Neurosci. (1996) [Pubmed]
  29. Role of the midbrain periaqueductal gray in maternal nurturance and aggression: c-fos and electrolytic lesion studies in lactating rats. Lonstein, J.S., Stern, J.M. J. Neurosci. (1997) [Pubmed]
  30. Differential visualization of dopamine and norepinephrine uptake sites in rat brain using [3H]mazindol autoradiography. Javitch, J.A., Strittmatter, S.M., Snyder, S.H. J. Neurosci. (1985) [Pubmed]
  31. Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Bao, S., Chan, V.T., Merzenich, M.M. Nature (2001) [Pubmed]
  32. Involvement of the endocannabinoid system in drug addiction. Maldonado, R., Valverde, O., Berrendero, F. Trends Neurosci. (2006) [Pubmed]
  33. DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens. Maldve, R.E., Zhang, T.A., Ferrani-Kile, K., Schreiber, S.S., Lippmann, M.J., Snyder, G.L., Fienberg, A.A., Leslie, S.W., Gonzales, R.A., Morrisett, R.A. Nat. Neurosci. (2002) [Pubmed]
  34. Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. Cruz, H.G., Ivanova, T., Lunn, M.L., Stoffel, M., Slesinger, P.A., Lüscher, C. Nat. Neurosci. (2004) [Pubmed]
  35. A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism. Kim, J.A., Pollak, K.A., Hjelmstad, G.O., Fields, H.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  36. Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Basile, A.S., Fedorova, I., Zapata, A., Liu, X., Shippenberg, T., Duttaroy, A., Yamada, M., Wess, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  37. Neurochemical and immunocytochemical studies of catecholamine system in the brindled mouse. Satoh, J., Irino, M., Martin, P.M., Mailman, R.B., Suzuki, K. J. Neuropathol. Exp. Neurol. (1991) [Pubmed]
  38. A response element for the homeodomain transcription factor Ptx3 in the tyrosine hydroxylase gene promoter. Cazorla, P., Smidt, M.P., O'Malley, K.L., Burbach, J.P. J. Neurochem. (2000) [Pubmed]
  39. Specific involvement of neurotensin type 1 receptor in the neurotensin-mediated in vivo dopamine efflux using knock-out mice. Leonetti, M., Brun, P., Clerget, M., Steinberg, R., Soubrié, P., Renaud, B., Suaud-Chagny, M.F. J. Neurochem. (2004) [Pubmed]
  40. Nicotine infusion modulates immobilization stress-triggered induction of gene expression of rat catecholamine biosynthetic enzymes. Serova, L., Danailov, E., Chamas, F., Sabban, E.L. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  41. Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study. Klitenick, M.A., DeWitte, P., Kalivas, P.W. J. Neurosci. (1992) [Pubmed]
  42. Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats. You, Z.B., Tzschentke, T.M., Brodin, E., Wise, R.A. J. Neurosci. (1998) [Pubmed]
  43. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. Nirenberg, M.J., Chan, J., Vaughan, R.A., Uhl, G.R., Kuhar, M.J., Pickel, V.M. J. Neurosci. (1997) [Pubmed]
  44. Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology. Rayport, S., Sulzer, D., Shi, W.X., Sawasdikosol, S., Monaco, J., Batson, D., Rajendran, G. J. Neurosci. (1992) [Pubmed]
 
WikiGenes - Universities