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MeSH Review

Ventral Tegmental Area

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Disease relevance of Ventral Tegmental Area


Psychiatry related information on Ventral Tegmental Area


High impact information on Ventral Tegmental Area


Chemical compound and disease context of Ventral Tegmental Area


Biological context of Ventral Tegmental Area


Anatomical context of Ventral Tegmental Area


Associations of Ventral Tegmental Area with chemical compounds

  • The cortex receives widespread projections from dopamine neurons in the ventral tegmental area (VTA), which are activated by new stimuli or unpredicted rewards, and are believed to provide a reinforcement signal for such learning-related cortical reorganization [31].
  • This system participates in the primary rewarding effects of cannabinoids, nicotine, alcohol and opioids, through the release of endocannabinoids in the ventral tegmental area [32].
  • We propose that DARPP-32 mediated blunting of the response to ethanol subsequent to activation of ventral tegmental area dopaminergic neurons initiates molecular alterations that influence synaptic plasticity in this circuit, thereby promoting the development of ethanol reinforcement [33].
  • Here we found that the coupling efficacy (EC(50)) of G-protein-gated inwardly rectifying potassium (GIRK, Kir3) channels to GABA(B) receptor was much lower in dopamine neurons than in GABA neurons of the ventral tegmental area (VTA), depending on the differential expression of GIRK subunits [34].
  • Although the cocaine-induced enhancements of both morphine CPP and U69593 CPA followed different time courses, suggesting different mechanisms, both effects were blocked by injection of the N-methyl-d-aspartate receptor antagonist MK-801 (0.5 nmol bilaterally) into the ventral tegmental area, immediately before the cocaine injection [35].

Gene context of Ventral Tegmental Area


Analytical, diagnostic and therapeutic context of Ventral Tegmental Area


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  31. Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Bao, S., Chan, V.T., Merzenich, M.M. Nature (2001) [Pubmed]
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  34. Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. Cruz, H.G., Ivanova, T., Lunn, M.L., Stoffel, M., Slesinger, P.A., Lüscher, C. Nat. Neurosci. (2004) [Pubmed]
  35. A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism. Kim, J.A., Pollak, K.A., Hjelmstad, G.O., Fields, H.L. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  36. Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia. Basile, A.S., Fedorova, I., Zapata, A., Liu, X., Shippenberg, T., Duttaroy, A., Yamada, M., Wess, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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  44. Identified postnatal mesolimbic dopamine neurons in culture: morphology and electrophysiology. Rayport, S., Sulzer, D., Shi, W.X., Sawasdikosol, S., Monaco, J., Batson, D., Rajendran, G. J. Neurosci. (1992) [Pubmed]
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