Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Scn8a - sodium channel, voltage gated, type VIII,...

Rattus norvegicus

Synonyms: NaCh6, PN4, Peripheral nerve protein type 4, Sodium channel 6, Sodium channel protein type 8 subunit alpha, ...

Dietrich, P.S. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Scn8a

In contrast, rPN4a shows no expression in brain and low-level expression in spinal cord, whereas in DRG its expression is comparable to that of NaCh6/Scn8a/rPN4 [1].
Functional analysis of these channels expressed in Xenopus oocytes showed that NaCh6/Scn8a/rPN4 and rPN4a exhibited similar properties, with V(1/2) approximately -100 mV for steady-state inactivation and V(1/2) approximately -40 mV for activation. rPN4a recovered from inactivation significantly faster than NaCh6/Scn8a/rPN4 [1].
NaCh6/Scn8a/rPN4 was inhibited by tetrodotoxin with an IC50 approximately 1 nM [1].
Tissue distribution analyzed by RT-PCR showed NaCh6/Scn8a/rPN4 to be expressed at its highest levels in rat brain, at moderate levels in spinal cord, and at lower levels in DRG, nodose ganglia, and superior cervical ganglia and to be absent from sciatic nerve, heart, and skeletal muscle [1].

References

Functional analysis of a voltage-gated sodium channel and its splice variant from rat dorsal root ganglia. Dietrich, P.S., McGivern, J.G., Delgado, S.G., Koch, B.D., Eglen, R.M., Hunter, J.C., Sangameswaran, L. J. Neurochem. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SCN8A	Bos taurus
SCN8A	Canis lupus familiaris
scn8ab	Danio rerio
scn8aa	Danio rerio
SCN8A	Gallus gallus
SCN8A	Homo sapiens
SCN8A	Macaca mulatta
Scn8a	Mus musculus
SCN8A	Pan troglodytes
LOC101731347	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share