Gene Review:
Tinag - tubulointerstitial nephritis antigen
Rattus norvegicus
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Disease relevance of Tinag
- However, Lewis rat does not demonstrate any immunoreactivity for TIN-ag and does not develop tubuloinsterstitial nephritis after injection of tubular basement membrane material [1].
- Tubulointerstitial nephritis antigen (TIN-ag) is a recently described basement membrane component reactive with autoantibodies in some forms of autoimmune mediated tubulointerstitial nephritis [1].
High impact information on Tinag
- RTPCR analysis of Lewis rat kidney cortex total RNA illustrated the expression of a TIN-ag gene product [1].
Biological context of Tinag
- Immunofluorescence studies using polyclonal and monoclonal antibodies have indicated a restrictive tissue distribution for TIN-ag, with the site of most prominent expression the kidney tubular basement membrane [1].
Analytical, diagnostic and therapeutic context of Tinag
- Western blotting demonstrated the presence of TIN-ag protein forms in kidney cortical homogenates of Lewis rat [1].
- Southern blotting of Lewis rat genomic DNA revealed the presence of gene sequences corresponding to TIN-ag [1].
References
- Detection of tubulointerstitial nephritis antigen (TIN-ag) in Lewis rat. Nelson, T.R., Butkowski, R.J., Michael, A.F., Charonis, A.S. Connect. Tissue Res. (1997) [Pubmed]
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