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Gene Review

foxa2  -  forkhead box A2

Danio rerio

Synonyms: Axial protein, Forkhead box protein A2, HNF-3B, SO:0000704, ax, ...
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High impact information on foxa2

  • Thus, Axial appears to be a target of both mesoderm induction and neural induction, leading to expression in cells of all three germ layers along the developing axis [1].
  • Taken together, our data suggest that Axial plays a crucial role in specification of both the axial mesendoderm and the ventral central nervous system [1].
  • The primary defects of cyclops mutants (lack of floor plate, deficiencies in the brain and cyclopia) correlate well with the expression domain of the Axial gene in wild-type neuroectoderm [1].
  • Our results suggest that both Axial (HNF3beta) and retinoic acid receptors are direct regulators of the sonic hedgehog gene [2].
  • In contrast to previously described zebrafish trunk LFP markers, like e.g. tal2 or foxa2, nkx2.2b is exclusively expressed in the LFP [3].

Biological context of foxa2


Anatomical context of foxa2

  • Endodermal expression of axl and shh is not affected by the mutations showing that development of the endoderm is under distinct control [5].

Other interactions of foxa2

  • We present a description of the expression of the HNF-3 beta homolog axial (axl) in the developing zebrafish up to larva stages and compare it with that of sonic hedgehog (shh) [5].


  1. Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryos. Strähle, U., Blader, P., Henrique, D., Ingham, P.W. Genes Dev. (1993) [Pubmed]
  2. Axial (HNF3beta) and retinoic acid receptors are regulators of the zebrafish sonic hedgehog promoter. Chang, B.E., Blader, P., Fischer, N., Ingham, P.W., Strähle, U. EMBO J. (1997) [Pubmed]
  3. Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk. Schäfer, M., Kinzel, D., Neuner, C., Schartl, M., Volff, J.N., Winkler, C. Mech. Dev. (2005) [Pubmed]
  4. fork head domain genes in zebrafish. Odenthal, J., Nüsslein-Volhard, C. Dev. Genes Evol. (1998) [Pubmed]
  5. Expression of axial and sonic hedgehog in wildtype and midline defective zebrafish embryos. Strähle, U., Blader, P., Ingham, P.W. Int. J. Dev. Biol. (1996) [Pubmed]
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