Gene Review:
Foxa2 - forkhead box A2
Mus musculus
Synonyms:
Forkhead box protein A2, HNF-3-beta, HNF-3B, HNF3-beta, HNF3beta, ...
- Expression and role of Foxa proteins in prostate cancer. Mirosevich, J., Gao, N., Gupta, A., Shappell, S.B., Jove, R., Matusik, R.J. Prostate (2006)
- Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Sund, N.J., Vatamaniuk, M.Z., Casey, M., Ang, S.L., Magnuson, M.A., Stoffers, D.A., Matschinsky, F.M., Kaestner, K.H. Genes Dev. (2001)
- HNF-3 beta as a regulator of floor plate development. Sasaki, H., Hogan, B.L. Cell (1994)
- HNF-3 beta is essential for node and notochord formation in mouse development. Ang, S.L., Rossant, J. Cell (1994)
- The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Weinstein, D.C., Ruiz i Altaba, A., Chen, W.S., Hoodless, P., Prezioso, V.R., Jessell, T.M., Darnell, J.E. Cell (1994)
- Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Wolfrum, C., Stoffel, M. Cell metabolism. (2006)
- Delayed activation of HNF-3 beta upon retinoic acid-induced teratocarcinoma cell differentiation. Reichel, R.R., Budhiraja, S., Jacob, A. Exp. Cell Res. (1994)
- Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Rausa, F.M., Tan, Y., Costa, R.H. Mol. Cell. Biol. (2003)
- Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. Hughes, D.E., Stolz, D.B., Yu, S., Tan, Y., Reddy, J.K., Watkins, S.C., Diehl, A.M., Costa, R.H. Hepatology (2003)
- Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. Wan, H., Dingle, S., Xu, Y., Besnard, V., Kaestner, K.H., Ang, S.L., Wert, S., Stahlman, M.T., Whitsett, J.A. J. Biol. Chem. (2005)
- The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis. Yu, X., Suzuki, K., Wang, Y., Gupta, A., Jin, R., Orgebin-Crist, M.C., Matusik, R. Mol. Endocrinol. (2006)
- A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Sasaki, H., Hui, C., Nakafuku, M., Kondoh, H. Development (1997)
- FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Hoodless, P.A., Pye, M., Chazaud, C., Labbé, E., Attisano, L., Rossant, J., Wrana, J.L. Genes Dev. (2001)
- Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Hu, T., Yamagishi, H., Maeda, J., McAnally, J., Yamagishi, C., Srivastava, D. Development (2004)
- Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Gao, N., Ishii, K., Mirosevich, J., Kuwajima, S., Oppenheimer, S.R., Roberts, R.L., Jiang, M., Yu, X., Shappell, S.B., Caprioli, R.M., Stoffel, M., Hayward, S.W., Matusik, R.J. Development (2005)
- Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. Foucher, I., Montesinos, M.L., Volovitch, M., Prochiantz, A., Trembleau, A. Development (2003)
- Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Zhang, L., Rubins, N.E., Ahima, R.S., Greenbaum, L.E., Kaestner, K.H. Cell metabolism. (2005)
- Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells. Ha, E., Yim, S.V., Chung, J.H., Yoon, K.S., Kang, I., Cho, Y.H., Baik, H.H. J. Pineal Res. (2006)
- Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Gao, N., White, P., Doliba, N., Golson, M.L., Matschinsky, F.M., Kaestner, K.H. Cell Metab. (2007)
- Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2. Rubins, N.E., Friedman, J.R., Le, P.P., Zhang, L., Brestelli, J., Kaestner, K.H. Mol. Cell. Biol. (2005)
- Identification of a transthyretin enhancer site that selectively binds the hepatocyte nuclear factor-3 beta isoform. Samadani, U., Qian, X., Costa, R.H. Gene Expr. (1996)
- Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta. Zhou, H., Hughes, D.E., Major, M.L., Yoo, K., Pesold, C., Costa, R.H. Gene Expr. (2001)
- Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Sawada, A., Nishizaki, Y., Sato, H., Yada, Y., Nakayama, R., Yamamoto, S., Nishioka, N., Kondoh, H., Sasaki, H. Development (2005)
- Role of Foxa-2 in adipocyte metabolism and differentiation. Wolfrum, C., Shih, D.Q., Kuwajima, S., Norris, A.W., Kahn, C.R., Stoffel, M. J. Clin. Invest. (2003)
- Hepatocyte-nuclear factor 3 beta gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene. Philippe, J. Mol. Endocrinol. (1995)
- Beta-catenin regulates differentiation of respiratory epithelial cells in vivo. Mucenski, M.L., Nation, J.M., Thitoff, A.R., Besnard, V., Xu, Y., Wert, S.E., Harada, N., Taketo, M.M., Stahlman, M.T., Whitsett, J.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryos. Rausa, F.M., Ye, H., Lim, L., Duncan, S.A., Costa, R.H. Methods (1998)
- Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Bellusci, S., Henderson, R., Winnier, G., Oikawa, T., Hogan, B.L. Development (1996)
- Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo. Camus, A., Perea-Gomez, A., Moreau, A., Collignon, J. Dev. Biol. (2006)
- Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Molotkov, A., Molotkova, N., Duester, G. Dev. Dyn. (2005)
- Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Gofflot, F., Hall, M., Morriss-Kay, G.M. Dev. Dyn. (1997)
- Expression of Foxa transcription factors in the developing and adult murine prostate. Mirosevich, J., Gao, N., Matusik, R.J. Prostate (2005)
- Foxa2 regulates multiple pathways of insulin secretion. Lantz, K.A., Vatamaniuk, M.Z., Brestelli, J.E., Friedman, J.R., Matschinsky, F.M., Kaestner, K.H. J. Clin. Invest. (2004)
- Foxa2 is required for transition to air breathing at birth. Wan, H., Xu, Y., Ikegami, M., Stahlman, M.T., Kaestner, K.H., Ang, S.L., Whitsett, J.A. Proc. Natl. Acad. Sci. U.S.A. (2004)
- The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. Weidenfeld, J., Shu, W., Zhang, L., Millar, S.E., Morrisey, E.E. J. Biol. Chem. (2002)