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Gene Review

pyya  -  peptide YYa

Danio rerio

Synonyms: Peptide YY, Peptide YY-A, Peptide YYa, SO:0000704, pyy, ...
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High impact information on pyy


Biological context of pyy

  • This suggests that npy and pyy arose from a common ancestral gene in a chromosomal duplication event that also involved the hox gene clusters [1].

Anatomical context of pyy

  • Functional expression of the lamprey receptor in a cell line facilitated specific binding of the three endogenous lamprey peptides NPY, peptide YY and peptide MY with picomolar affinities [2].

Associations of pyy with chemical compounds


  1. Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. Söderberg, C., Wraith, A., Ringvall, M., Yan, Y.L., Postlethwait, J.H., Brodin, L., Larhammar, D. J. Neurochem. (2000) [Pubmed]
  2. A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. A potential ancestral gene. Salaneck, E., Fredriksson, R., Larson, E.T., Conlon, J.M., Larhammar, D. Eur. J. Biochem. (2001) [Pubmed]
  3. Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor. Arvidsson, A.K., Wraith, A., Jönsson-Rylander, A.C., Larhammar, D. Regul. Pept. (1998) [Pubmed]
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