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Gene Review

PYY  -  peptide YY

Bos taurus

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High impact information on PYY


Biological context of PYY

  • NPY, Y1RL, and PYY displayed a concentration that inhibits the specific binding by 50% IC50 (nM) values of 4.06 +/- 1.66 (n = 4), 2.94 +/- 0.75 (n = 5), and 18.36 +/- 10.36 (n = 3), respectively [6].

Anatomical context of PYY

  • The study indicates a modulatory role for NPY, PYY and bPP in synaptic interactions within the enteric nervous system [7].
  • Saturation and competition binding data with PYY, NPY-(18-36) and NPY itself fit with a single class of sites: for the radioligand KD = 1.4 +/- 0.5 nM, Bmax = 434 +/- 180 fmol/mg protein in frontal cortex, KD = 0.7 +/- 0.2 nM, Bmax = 267 +/- 50 fmol/mg protein in hippocampus [8].

Associations of PYY with chemical compounds

  • 4. The results suggest that NPY, PYY and bPP, but not aPP, act presynaptically to inhibit acetylcholine release from myenteric neurones of the gastric corpus, thereby suppressing fEPSPs [7].


  1. Seminalplasmin: recent evolution of another member of the neuropeptide Y gene family. Herzog, H., Hort, Y., Schneider, R., Shine, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Neuropeptide Y inhibits chromaffin cell nicotinic receptor-stimulated tyrosine hydroxylase activity through a receptor-linked G protein-mediated process. Zheng, J., Zhang, P., Hexum, T.D. Mol. Pharmacol. (1997) [Pubmed]
  3. Immunocytochemical evidence for a substance related to the bovine pancreatic polypeptide-peptide YY group of peptides in the human fetal gastrointestinal tract. Leduque, P., Paulin, C., Dubois, P.M. Regul. Pept. (1983) [Pubmed]
  4. Neuropeptide Y receptor in bovine hippocampus is a Y2 receptor. Li, W., MacDonald, R.G., Hexum, T.D. Life Sci. (1992) [Pubmed]
  5. Immunohistochemical study on the distribution of endocrine cells in the gastrointestinal tract of the babirusa, Babyrousa babyrussa (Suidae). Agungpriyono, S., Macdonald, A.A., Leus, K.Y., Kitamura, N., Adnyane, I.K., Goodall, G.P., Hondo, E., Yamada, J. Anatomia, histologia, embryologia. (2000) [Pubmed]
  6. Specific 125I neuropeptide Y binding to intact cultured bovine adrenal medulla capillary endothelial cells. Sanabria, P., Silva, W.I. Microcirculation (New York, N.Y. : 1994) (1994) [Pubmed]
  7. Presynaptic inhibitory effects of the peptides NPY, PYY and PP on nicotinic EPSPs in guinea-pig gastric myenteric neurones. Schemann, M., Tamura, K. J. Physiol. (Lond.) (1992) [Pubmed]
  8. Neuropeptide Y receptors from calf brain: effect of crude Conus venom preparations on [3H]NPY binding. Czerwiec, E., de Backer, J.P., Vauquelin, G., Vanderheyden, P.M. Neurochem. Int. (1996) [Pubmed]
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