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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

her6  -  hairy-related 6

Danio rerio

Synonyms: HER-6, SO:0000704, cb129
 
 
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High impact information on her6

  • In hdac1 mutant embryos, the Notch-responsive E(spl)-related neurogenic gene her6 is ectopically expressed at distinct sites within the developing CNS and proneural gene expression is correspondingly reduced or eliminated [1].
  • The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites [2].
  • In order to validate our findings, we employed three approaches: (1) microarray expression analysis of genes previously implicated in fin regeneration, (2) RT-PCR analysis of genes newly identified as differentially expressed during regeneration, and (3) in situ hybridization of the up-regulated genes bambi, dlx5A, and her6 [3].

References

  1. Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling. Cunliffe, V.T. Development (2004) [Pubmed]
  2. The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites. Pasini, A., Henrique, D., Wilkinson, D.G. Mech. Dev. (2001) [Pubmed]
  3. Transcriptional profiling of caudal fin regeneration in zebrafish. Schebesta, M., Lien, C.L., Engel, F.B., Keating, M.T. ScientificWorldJournal (2006) [Pubmed]
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