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Gene Review

hoxd4a  -  homeobox D4a

Danio rerio

Synonyms: Homeobox protein Hox-D4a, Hox-D4, SO:0000704, etID309823.9, etID37000.9, ...
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High impact information on hoxd4a

  • Additionally, stage-matched zebrafish embryos having decreased pax6a and/or pax6b activity display malformed rhombomere boundaries and an anteriorized hoxd4a expression border [1].
  • We show that early zebrafish rhombomere-specification genes, including vhnf1 in r5-r6 and hoxd4a in r7, initiate expression sequentially in the hindbrain, each adjacent to the source of RA synthesis in paraxial mesoderm [2].


  1. Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Nolte, C., Rastegar, M., Amores, A., Bouchard, M., Grote, D., Maas, R., Kovacs, E.N., Postlethwait, J., Rambaldi, I., Rowan, S., Yan, Y.L., Zhang, F., Featherstone, M. Dev. Biol. (2006) [Pubmed]
  2. Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Maves, L., Kimmel, C.B. Dev. Biol. (2005) [Pubmed]
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