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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ANXA2P3  -  annexin A2 pseudogene 3

Homo sapiens

Synonyms: ANX2L3, ANX2P3, LIP2, LPC2C
 
 
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Disease relevance of ANXA2P3

  • The lip2 gene from the antarctic psychotroph Moraxella TA144 was sequenced [1].
 

High impact information on ANXA2P3

  • The LIP2 gene is at least 40 kb long and consists of 13 exons [2].
  • The three pseudogenes present typical features of retroposons and, together with the gene, probably represent the entire LIP2 multigene family [2].
  • These results suggest a role for LIP1 and LIP2 in cell survival [3].
  • In addition, LIP2 was expressed consistently in cecum contents but was undetectable in infected oral tissues suggesting LIP2 may be important for alimentary tract colonization, but not oral infection [4].
  • The primary structure of the Lip2 preprotein deduced from the nucleotide sequence is composed of 433 amino acids with a predicted Mr of 47,222 [1].
 

Chemical compound and disease context of ANXA2P3

References

  1. Nucleotide sequence of the lipase gene lip2 from the antarctic psychrotroph Moraxella TA144 and site-specific mutagenesis of the conserved serine and histidine residues. Feller, G., Thiry, M., Gerday, C. DNA Cell Biol. (1991) [Pubmed]
  2. Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication. Spano, F., Raugei, G., Palla, E., Colella, C., Melli, M. Gene (1990) [Pubmed]
  3. Multiple biological activities for two peptides derived from the nerve growth factor precursor. Dicou, E. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Differential Candida albicans lipase gene expression during alimentary tract colonization and infection. Schofield, D.A., Westwater, C., Warner, T., Balish, E. FEMS Microbiol. Lett. (2005) [Pubmed]
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