Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

thrb - thyroid hormone receptor beta

Danio rerio

Synonyms: NR1A2, Nuclear receptor subfamily 1 group A member 2, SO:0000704, TR-beta, TR[b]1, ...

Marchand, O. et al., Liu, Y.W. et al.

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High impact information on thrb

In addition, we isolated a cDNA encoding TRbeta in the Atlantic salmon (Salmo salar) encoding a functional thyroid hormone receptor which binds specific thyroid hormone response elements and regulates transcription in response to thyroid hormones [1].
Interestingly, this approach allowed us to isolate (from tilapia and salmon) several new TRalpha or TRbeta isoforms resulting from alternative splicing [1].
In this report, we describe an efficient reverse transcription/PCR procedure that allows the isolation of large fragments corresponding to TRalpha and TRbeta of a wide range of teleost fish [1].

Associations of thrb with chemical compounds

We propose that the embryonic to larval transitory phase in many teleost species is characterized by its dependency on the timely synthesis of TH and the concomitant autoinductive increase in TR beta mRNA levels [2].

References

Molecular cloning and characterization of thyroid hormone receptors in teleost fish. Marchand, O., Safi, R., Escriva, H., Van Rompaey, E., Prunet, P., Laudet, V. J. Mol. Endocrinol. (2001) [Pubmed]
Thyroid hormones are important for embryonic to larval transitory phase in zebrafish. Liu, Y.W., Chan, W.K. Differentiation (2002) [Pubmed]

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