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Gene Review:

raraa - retinoic acid receptor, alpha a

Danio rerio

Synonyms: Nuclear receptor subfamily 1 group B member 1-A, RAR-alpha-2.A, RAR-alpha-A, Retinoic acid receptor alpha, Retinoic acid receptor alpha-2.A, ...

Hale, L.A. et al., Joore, J. et al.

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High impact information on raraa

Treatment of embryos with RA induces ectopic zRAR gamma expression in anterior brain structures and both zRAR alpha and zRAR gamma expression in the eyes [1].
Zygotic expression of rarab largely overlaps that of raraa, except that in later stages rarab is expressed more broadly in the brain and in the pectoral fin bud and pharyngeal arches [2].
Zygotic expression of raraa occurs predominantly in the hindbrain, lateral mesoderm, and tailbud [2].

Biological context of raraa

Analysis of phylogenies and conserved syntenies showed that the three cloned zebrafish rar genes include raraa and rarab, which are co-orthologs of tetrapod Rara, and rarg, which is the zebrafish ortholog of tetrapod Rarg [2].
Since the development of all of these structures has been shown to be affected by exogenous RA, our data suggest a role for zRAR alpha and zRAR gamma in the establishment of the RA phenotype in zebrafish [1].

Associations of raraa with chemical compounds

Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development [2].

References

Effects of retinoic acid on the expression of retinoic acid receptors during zebrafish embryogenesis. Joore, J., van der Lans, G.B., Lanser, P.H., Vervaart, J.M., Zivkovic, D., Speksnijder, J.E., Kruijer, W. Mech. Dev. (1994) [Pubmed]
Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development. Hale, L.A., Tallafuss, A., Yan, Y.L., Dudley, L., Eisen, J.S., Postlethwait, J.H. Gene Expr. Patterns (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

RARA	Bos taurus
RARA	Canis lupus familiaris
rarab	Danio rerio
RARA	Gallus gallus
RARA	Homo sapiens
Rara	Mus musculus
Rara	Rattus norvegicus
rara	Xenopus (Silurana) tropicalis

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