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Gene Review

RARA  -  retinoic acid receptor, alpha

Bos taurus

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Disease relevance of RARA


High impact information on RARA

  • Smaller granular deposits of immune complexes, C3, and the MAC were observed in the subendothelial region of the lamina rara interna and the lamina densa [3].
  • There were three sites at which the passage of IgG across the basement membrane was hindered: between blood plasma and the lamina rara interna, between the lamina densa and the lamina rara externa, and between the lamina rara externa and the urinary space [4].
  • The presence of heparan sulfate proteoglycan (HSPG) in anionic sites in the lamina rara interna of glomerular basement membrane suggests that the proteoglycan may be deposited by the glomerular endothelial cells (GEndo) [5].

Analytical, diagnostic and therapeutic context of RARA


  1. Localization of cationic proteins derived from platelets and polymorphonuclear neutrophils and local loss of anionic sites in glomeruli of rabbits with experimentally-induced acute serum sickness. Camussi, G., Tetta, C., Meroni, M., Torri-Tarelli, L., Roffinello, C., Alberton, A., Deregibus, C., Sessa, A. Lab. Invest. (1986) [Pubmed]
  2. Visible light exposure induces VEGF gene expression through activation of retinoic acid receptor-alpha in retinoblastoma Y79 cells. Akiyama, H., Tanaka, T., Doi, H., Kanai, H., Maeno, T., Itakura, H., Iida, T., Kimura, Y., Kishi, S., Kurabayashi, M. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  3. Localization of the membrane attack complex (MAC) in experimental immune complex glomerulonephritis. Koffler, D., Biesecker, G., Noble, B., Andres, G.A., Martinez-Hernandez, A. J. Exp. Med. (1983) [Pubmed]
  4. The glomerular ultrastructural distribution of immunoglobulin G in hyperalbuminaemic (protein-overload) proteinuria. Howie, A.J., Bliss, D.J., Brewer, D.B. J. Pathol. (1985) [Pubmed]
  5. Regulation of glomerular endothelial cell proteoglycans by glucose. Ha, T.S., Duraisamy, S., Faulkner, J.L., Kasinath, B.S. J. Korean Med. Sci. (2004) [Pubmed]
  6. Bovine cumulus-granulosa cells contain biologically active retinoid receptors that can respond to retinoic acid. Mohan, M., Thirumalapura, N.R., Malayer, J. Reprod. Biol. Endocrinol. (2003) [Pubmed]
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